Flashcards in CNS Pharmacology Overview-Review Deck (10):
Insomnia results from increased ______________.
acetylcholine (hence first-generation antihistamines – which are also anticholinergic – can treat insomnia)
Why would you give memantine to someone with Alzheimer's?
Because Alzheimer's presents with excess glutamate activity (and memantine is an NMDA receptor antagonist)
General anesthetics work by ________________.
blocking NMDA receptors, thus decreasing glutamate
What are the stages of anesthesia?
Stage I: analgesia and loss of consciousness
Stage II: unconscious but most reflexes preserved
Stage III: three planes, ranging from cessation of eye movements to paralysis of intercostal muscles
Stage IV: medullary paralysis
Increases in sodium chloride intake does what to lithium blood levels?
True or false: weight gain is common in the first few months that a patient is taking an SSRI.
False. Generally, nausea and vomiting come in the first few months and weight gain happens after the first few months.
Review the "Lifetime U.S. Prevalence of Psychiatric Disorders" chart in Dr. Schneck's presentation.
Impulse control disorder (e.g., ADHD, ODD, CD): 24.8%
Any mood disorder: 21%
Major depressive disorder: 17%
Why does the VSCC-blocking action of lamotrigine aid in its treatment of epilepsy?
Because the VSCC cause glutamate release, and epilepsy is characterized by excess glutamate activity.
Recall that cocaine can also cause _______________ (not a sympathetic symptom).