Flashcards in Neuromuscular Pharmacology Deck (9):
What is a good mnemonic for remembering the non-depolarizing neuromuscular blockers?
They all have "-cur-" in them, because they are related to curare! (panCURonium, ronCURonium, veCURonium)
What specific V-SNARE is clipped by botulinum toxin?
Why does botulinum lead to flaccid paralysis while tetanus toxin leads to spastic paralysis?
Botulinum targets the NMJ presynaptic neurons, while tetanus targets inhibitory GABA channels.
How does black widow toxin exert its effect?
It perforates the presynaptic membrane, thus leading to excessive calcium entry and inappropriate acetylcholine release. Ultimately this leads to depolarization blockade – resulting in respiratory paralysis similar to botulism toxicity.
What toxin blocks voltage-sensitive sodium channels?
Lamotrigine blocks ___________.
voltage-sensitive calcium channels
What does dantrolene block? In what circumstance is it used?
It blocks voltage-sensitive calcium channels – which get stuck open in malignant hyperthermia
Describe the three drugs that make up the lethal-injection cocktail.
Midazolam – general anesthetic to make the person unconscious
Pancuronium – paralyze the respiratory muscles
Potassium chloride – stop the heart