Neuromuscular Pharmacology Flashcards Preview

MS2 - Nervous System > Neuromuscular Pharmacology > Flashcards

Flashcards in Neuromuscular Pharmacology Deck (9):
1

What is a good mnemonic for remembering the non-depolarizing neuromuscular blockers?

They all have "-cur-" in them, because they are related to curare! (panCURonium, ronCURonium, veCURonium)

2

What specific V-SNARE is clipped by botulinum toxin?

Synaptobrevin

3

Why does botulinum lead to flaccid paralysis while tetanus toxin leads to spastic paralysis?

Botulinum targets the NMJ presynaptic neurons, while tetanus targets inhibitory GABA channels.

4

How does black widow toxin exert its effect?

It perforates the presynaptic membrane, thus leading to excessive calcium entry and inappropriate acetylcholine release. Ultimately this leads to depolarization blockade – resulting in respiratory paralysis similar to botulism toxicity.

5

What toxin blocks voltage-sensitive sodium channels?

Tetrodotoxin

6

Lamotrigine blocks ___________.

voltage-sensitive calcium channels

7

What does dantrolene block? In what circumstance is it used?

It blocks voltage-sensitive calcium channels – which get stuck open in malignant hyperthermia

8

Describe the three drugs that make up the lethal-injection cocktail.

Midazolam – general anesthetic to make the person unconscious
Pancuronium – paralyze the respiratory muscles
Potassium chloride – stop the heart

9

Edrophonium, neostigmine, pyridostigmine, and physostigmine can reverse what toxicity?

Overdose with non-depolarizing neuromuscular junction blockers (such as pancuronium or curare)

Decks in MS2 - Nervous System Class (111):