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MS2 - Nervous System > Degenerative Disease > Flashcards

Flashcards in Degenerative Disease Deck (14):
1

__________ reflexes are lost in Parkinson's.

Righting (such as throwing your arms out when you slip to achieve balance)

2

What are the defining features of Lewy body dementia?

Early Parkinsonian features (tremors)
Psychosis
Fluctuating levels of consciousness

3

Describe progressive supranuclear palsy (PSP).

Bradykinesia
Rigidity
Falls
Abnormal vertical eye movements (specifically loss of eye reflexes that normally occur when you're moving your head while trying to focus on a fixed object)

4

Those with Huntington's have fleeting movements called __________.

chorea

5

Young onset of Alzheimer's often presents with __________ mutations.

presenilin 1

6

Tremor, rigidity, and bradykinesia are characteristic of _____________.

Parkinson's disease

7

True or false: the normal form of the protein that leads to Creutzfeldt-Jakob disease is expressed in most human tissues.

True! PrP is found everywhere in the body, but the highest concentrations are in the CNS.

8

What causes vCJD?

Bovine-to-human transmission

9

The neurotransmitter involved in the dementia that presents with personality changes in the absence of memory loss is also down-regulated in which psychiatric disease?

Depression (the neurotransmitter being serotonin)

10

What histologic features are necessary for a diagnosis of Alzheimer's?

Neurofibrillary tangles and neuritic plaques

11

What brain structures are primarily affected in Alzheimer's?

The cortex and hippocampus – the deep nuclei are usually spared

12

Disturbances of synuclein are seen in those displaying what symptoms?

Parkinson's: tremor, bradykinesia, rigidity
Lewy body: psychosis, early Parkinsonian features, dementia

13

Amyotrophic lateral sclerosis often presents with buildup of what protein?

Ubiquitin

14

__________ can present with a wide variety of molecular deposits, including a recently discovered dipeptide.

Fronto-temporal dementia

Decks in MS2 - Nervous System Class (111):