Flashcards in Pharmacologic Treatment of Headaches Deck (10):
Which abortive treatments for migraine should be avoided in someone with ischemic vascular disease?
NSAIDs are avoided in those with _________. Why?
acute gastritis; NSAIDs (most) inhibit COX-1, which secretes protective mucus in the stomach
Ergots are ____________ treatments.
The vascular events in migraines appear to have two phases: ________________.
first vasoconstriction then vasodilation
Drug delivery can be impacted by the tendency to have _____________ with migraines.
nausea, vomiting, or GI dysmotility
Do not concurrently use ergots and triptans. Why?
Because their vasoconstrictive effects can be additive
What is the mechanism of ergots?
When should you initiate prophylactic treatment for migraines?
When the migraines are frequent (more than four per month), disabling, or long-lasting
Which should you use first, triptans or ergots?
Triptans. Ergots have greater toxicity.