Pharmacologic Treatment of Headaches Flashcards Preview

MS2 - Nervous System > Pharmacologic Treatment of Headaches > Flashcards

Flashcards in Pharmacologic Treatment of Headaches Deck (10):
1

Which abortive treatments for migraine should be avoided in someone with ischemic vascular disease?

Triptans
Ergots

2

NSAIDs are avoided in those with _________. Why?

acute gastritis; NSAIDs (most) inhibit COX-1, which secretes protective mucus in the stomach

3

Ergots are ____________ treatments.

abortive

4

The vascular events in migraines appear to have two phases: ________________.

first vasoconstriction then vasodilation

5

Drug delivery can be impacted by the tendency to have _____________ with migraines.

nausea, vomiting, or GI dysmotility

6

Do not concurrently use ergots and triptans. Why?

Because their vasoconstrictive effects can be additive

7

What is the mechanism of ergots?

5HT-1b/1d agonist

8

When should you initiate prophylactic treatment for migraines?

When the migraines are frequent (more than four per month), disabling, or long-lasting

9

Which should you use first, triptans or ergots?

Triptans. Ergots have greater toxicity.

10

How long do prophylactic treatments take to become effective?

4-6 weeks

Decks in MS2 - Nervous System Class (111):