Flashcards in Pharmacotherapy of Sleep Disorders Deck (14):
What is the brand name of zolpidem?
Eszopiclone is sold under the brand name ___________.
True or false: both benzodiazepines and zolpidem bind to the alpha-1 subunit.
True, but the Z drugs bind only to the alpha-1 subunit while benzodiazepines bind to alpha-1 to alpha-5.
Why would you be wary prescribing a daily dose of flurazepam?
Flurazepam has the longest half life; thus, regular doses can accumulate – particularly in the elderly.
Which drug is best for middle-of-the-night awakenings?
Ramelteon is best for ______________.
problems with sleep onset
_____________ plays a key role in maintaining wakefulness throughout the day. Lack of it leads to narcolepsy.
What is the mechanism of suvorexant?
It is an orexin receptor antagonist.
True or false: it is ok to chronically treat insomnia with antihistamines.
One of the reasons the Z drugs are superior to benzodiazepines is that Z drugs have no effect on ____________, while benzodiazepines are known to decrease all three.
stages 3, 4, and REM sleep
The best Z drug for problems with sleep onset is _____________.
zaleplon ("to help with your zaleplONSET")
Why is triazolam prescribed more often than the other benzodiazepines in the treatment of insomnia?
Because it has a very short half-life (2.5 hours)
True or false: ramelteon is a controlled substance.