Flashcards in Anxiolytic Agents Deck (15):
Serotonin agents stimulate anxiolysis via the 5HT receptors in the nucleus of __________.
Buspirone has what mechanism?
Agonist of the 5HT1A receptor; it is a weaker anxiolytic than GABA, but it has a fewer side effects; takes 2-4 weeks to become effective
True or false: benzodiazepines cannot produce anesthesia.
True... just conscious sedation
Why do benzodiazepines produce anterograde amnesia?
Because they decrease the release of glutamate, and glutamate is the neurotransmitter used by memory-forming neurons
True or false: GABA is needed for benzodiazepines to work.
True or false: flumazenil can be used for barbiturate overdose.
False. Although flumazenil antagonizes the GABA-A channel, it does so at a different site than barbiturates and alcohol. It can treat overdose with Z drugs.
Benzodiazepines cause the GABA channel to open _____________, while barbiturates and alcohol cause GABA channels to open _____________.
more frequently; for longer
True or false: the "z" drugs (eszopiclone, zolpidem, zaleplon) cannot treat seizures.
True. While they can in theory, they put people to sleep first and are thus not an effective anticonvulsant.
Benzodiazepines are typically dangerous only when ____________________.
combined with ethanol or barbiturates
True or false: benzodiazepines are potent inducers of CYP450.
False. But they are metabolized by CYP450, so use caution in patients who might have upregulated or inhibited CYP450.
Inhalational anesthetics also work by _______________.
potentiating GABA receptors
True or false: the benzodiazepines and "Z" drugs bind the same subunit of GABA.
True – the alpha-1 subunit; but the benzodiazepines also bind the other subunits, while the Z drugs do not.
The -zepams are conjugated where?
Extrahepatically! The -olams, however, are not: think -OLam = Old Liver.
True or false: benzodiazepines cause retrograde amnesia.
False. They cause anterograde amnesia.