Bone Pathology I: Metabolic Bone Disease Flashcards Preview

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Flashcards in Bone Pathology I: Metabolic Bone Disease Deck (29):
1

What cells develop into osteoblasts?

Osteoprogenitor Cells

2

Which cells build bone?

Osteoblasts

3

What are osteoblasts surrounded by matrix called?

Osteocytes

4

What cells are responsible for bone resorption and differentiate from monocytes?

Osteoclasts

5

Fracture

Discontinuity of the bone

6

Callus

Osteogenic or chondrogenic reparative granulation tissue

7

What is the most common bone disease?

Osteoporosis

8

Osteoporosis

Trabecular bone loses mass and interconnections that lead to compromized bone strength

9

What remains normal in osteoporosis?

Mineralization

10

Type I Osteoporosis

Mainly trabecular bones and is related to menopause

11

Type II Osteoporosis

Seen in older patients and is in trabecular AND cortical bones and is related to aging

12

What drugs may cause secondary osteoporosis?

- Corticosteroids
- Alcohol

13

What DEXA score shows osteoporosis?

-2.5 or less

14

What is the treatment for osteoporosis?

- Vitamin D
- Exercise
- Estrogen Replacement

15

Rickets/Osteomalacia

Vitamin D deficiency leads to mineralization defect which can cause structural abnormalities

16

Osteopenia

Loss of skeletal mass

17

Rickets

Seen in children where the growth plate is not adequately mineralized leading to irregular and thickened growth plate

18

What is a clinical sign of rickets?

Bowed legs

19

What is the treatment for rickets/osteomalacia?

Vitamin D

20

Hyperparathyroidism

Increased PTH level leads to increased osteoclast action and bone resorption

21

Osteitis Fibrosa Cystica

Bone is replaced with fibrous tissue with cystic change

22

Paget Disease of Bone

Caused by osteoclast dysfuncton from increased RANK expression and induction of IL-6

23

What are some clinical features of Paget Disease of Bone?

- Thickening of skull
- Bowing of legs

24

What serum marker is elevated in Paget Disease of Bone?

Elevated alkaline phosphatase

25

What is used to treat Paget Disease?

- Bisphosphonates - apoptosis of osteoclasts
- Calcitonin - inhibits osteoclast function

26

What are the 3 phases of Paget's Disease of Bone?

1. osteoclast overactivity
2. osteoblast activity
3. bone sclerosis

27

Osteogenesis Imperfecta

Defect in type I collagen leads to brittle bone disease

28

Achondroplasia

Defect in signal transduction from FGFR3 mutation causes dwarfism due to growth plate abnormality

29

Osteonecrosis

Bone death with many causes from ischemia to corticosterois

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