Flashcards in Bone Pathology I: Metabolic Bone Disease Deck (29):
What cells develop into osteoblasts?
Which cells build bone?
What are osteoblasts surrounded by matrix called?
What cells are responsible for bone resorption and differentiate from monocytes?
Discontinuity of the bone
Osteogenic or chondrogenic reparative granulation tissue
What is the most common bone disease?
Trabecular bone loses mass and interconnections that lead to compromized bone strength
What remains normal in osteoporosis?
Type I Osteoporosis
Mainly trabecular bones and is related to menopause
Type II Osteoporosis
Seen in older patients and is in trabecular AND cortical bones and is related to aging
What drugs may cause secondary osteoporosis?
What DEXA score shows osteoporosis?
-2.5 or less
What is the treatment for osteoporosis?
- Vitamin D
- Estrogen Replacement
Vitamin D deficiency leads to mineralization defect which can cause structural abnormalities
Loss of skeletal mass
Seen in children where the growth plate is not adequately mineralized leading to irregular and thickened growth plate
What is a clinical sign of rickets?
What is the treatment for rickets/osteomalacia?
Increased PTH level leads to increased osteoclast action and bone resorption
Osteitis Fibrosa Cystica
Bone is replaced with fibrous tissue with cystic change
Paget Disease of Bone
Caused by osteoclast dysfuncton from increased RANK expression and induction of IL-6
What are some clinical features of Paget Disease of Bone?
- Thickening of skull
- Bowing of legs
What serum marker is elevated in Paget Disease of Bone?
Elevated alkaline phosphatase
What is used to treat Paget Disease?
- Bisphosphonates - apoptosis of osteoclasts
- Calcitonin - inhibits osteoclast function
What are the 3 phases of Paget's Disease of Bone?
1. osteoclast overactivity
2. osteoblast activity
3. bone sclerosis
Defect in type I collagen leads to brittle bone disease
Defect in signal transduction from FGFR3 mutation causes dwarfism due to growth plate abnormality