CNS Infections Flashcards Preview

Pathology > CNS Infections > Flashcards

Flashcards in CNS Infections Deck (27):
1

Meningitis

Inflammation of the leptomeniniges

2

Encephalitis

Infection of the brain parenchyma - neurons and glial cells

3

Brain Abscess

Localized brain infection

4

What is fungal meningitis associated with?

Immune-compromisded state

5

What is aseptic meningitis associated with?

Viral meningitis

6

Common cause of meningitis in neonates...

– Group B streptococci
– Aerobic Gram-negative bacilli (E. coli)

7

Common cause of meningitis in infants less than 1 year...

– S. pneumoniae (Pneumococcus)
– Haemophilus influenzae – less common now due to vaccination

8

Common cause of meningitis in teenagers...

– Neisseria meningitis
– H. influenzae
– S. pneumoniae

9

Common cause of meningitis in adults...

– S. pneumoniae
– Neisseria meningitidis

10

Common cause of meningitis in elderly...

– L. monocytogenes
– Pseudomonas aeruginosa (less common)

11

What are the causative agents of chronic meningitis?

- TB
- Fungal - Cryptococcus/Histoplasma
- Syphilis
- Borrelia (rare)

12

What cells are found with bacterial meningitis in the CSF?

Neutrophils

13

What cells are found with viral meningitis in the CSF?

Lymphocytes

14

What cells are found with TB meningitis in the CSF?

Lymphocytes

15

What is the most common cerebral parasite?

Taenia solium - cysticercosis

16

How can cysticercosis present?

Seizures

17

What are the TORCH infections?

Toxoplasmosis
Others
Rubella
CMV
HSV

18

What viruses prefer to attack motor neurons?

Polio Virus and Enterovirus

19

What matter of the CNS is more involved with viral encephalitis?

Greater gray matter involvement

20

Polio Encephalitis

Fecal-oral transmission with infection and destruction of anterior horn cells - LMN

21

What are Negri bodies indicative of?

Rabies

22

What area of the brain does Herpes encephalitis localize to?

Medial temporal lobes - edema, hemorrhage and necrosis

23

Who are the people affected with CNS infections by CMV?

Neonates and AIDs patients

24

What is the cause of progressive multifocal leukoencephalopathy?

Caused by JC virus - usually the immuno compromised

25

What are the characteristics of progressive multifocal leukoencephalopathy?

– Loss of myelin (with axonal sparing)
– Bizarre astrocytes
– Oligodendroglial inclusions

26

What is characteristic of HIV encephalitis?

Widespread microglial nodule encephalitis with multinucleated giant cells

27

Vacuolar Myelopathy

– Spastic paraparesis with hyperreflexia and ataxia
– Vacuolation of spinal cord white matter

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