Chronic Inflammation Flashcards Preview

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Flashcards in Chronic Inflammation Deck (13):
1

What is chronic inflammation characterized by?

– Accumulation of lymphocytes and macrophages
– Proliferating blood vessels
– Formation of connective tissue

2

What cell type is predominant in chronic inflammation?

Macrophages

3

What are some possible causes of chronic inflammation?

- inability to eradicate pathogen due to drug resistance or it being intracellular
- persistent exposure to an auto-Ag that cannot be eliminated

4

What cell type dominates acute inflammation?

Neutrophils

5

What is the effect of chronic high levels of inflammatory cytokines on the liver?

Increased rates of hepatic production of defense proteins which will lead to decreased albumin production.

6

What is the function of hepcidin?

Hepcidin regulates iron and causes decreased availability to the bone marrow as well as bacteria.

7

What is a granuloma?

Characteristic inflammation with microbes that are immune to intracellular killing mechanisms (TB) that forms a caseous center surrounded by macrophages to wall it off

8

What can prolonged increased hepcidin cause?

Anemia

9

What is the function of C-Reactive Protein (CRP)?

IT is linked to IL-6 and indicates an inflammatory response

10

What can give a false CRP positive?

Obesity

11

What is the erythrocyte sedimentation rate (ESR)?

Inflammation will increase IgG and fibrinogen which causes RBCs to fall rapidly in a column of plasma

12

What is leukopenia?

Decrease in WBCs in the blood

13

What is leukemia reaction?

Increased WBCs in response to stress/infection

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