Respiratory Viruses II Flashcards Preview

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Flashcards in Respiratory Viruses II Deck (18):
1

Why do respiratory syncytial virus and influenza peak rates in the winter?

They are stabilized by low temperature and low humidity

2

Do you get long term immunity from RSV infection?

No - only short term immunity with less severe reinfection

3

How is RSV transmitted?

Respiratory droplets

4

What is the presentation of RSV in infants?

Severe lower respiratory tract infection in children

5

What is the pathogenesis of RSV?

Necrosis of bronchiolar epithelium that leads to the occlusion of bronchioles with mucus and cellular debris leading to hyperinflation and air trapping

6

What is the current recommended mode of detection for RSV?

RT-PCR

7

Is there a vaccine or treatment for RSV?

No - but there is preventative treatment

8

What is the preventative treatment for RSV?

Palivizumab - monoclonal antibody against RSV entry to cells

9

Why did the killed virus vaccine for RSV in the 1960s cause more severe disease?

The vaccine was made to the post fusion RSV protein which facilitated disease rather than neutralizing it

10

What virus can present similarly to RSV but is not RSV?

Human Metapneumovirus

11

What is croup in an infant suggestive of?

- Parainfluenza
- Coronavirus - more rare

12

Does parainfluenza lead to long term immunity?

No

13

Is there a vaccine for parainfluenza virus?

No

14

What is negative strand RNA?

Goes 3' to 5' instead

15

What must happen with negative strand viruses first on invasion?

Conversion to a positive strand

16

What are positive strand RNAs identical to?

mRNA

17

What are the syncytia generated from RSV?

The syncytia result from the amalgamation of cells with the loss of cell borders, multinucleated cells and intracytoplasmic inclusions.

18

Ribavirin MOA

Cause more mistakes in the viral replication with increased mutations to prevent efficient replication of viruses

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