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Flashcards in Oncogenic Viruses Deck (13):
1

What viruses are indirectly linked to HCC?

HBV and HBC

2

What virus is linked with Kaposi sarcoma?

HHV-8

3

What virus is linked with cervical carcinoma?

HPV

4

What is the most common viral associated cancer in males?

Liver Cancer

5

What is the most common viral associated cancer in females?

Cervical Cancer

6

What are the high risk HPV types?

16, 18, 31 and 33

7

What are the low risk HPV types?

6 and 11

8

What are the E genes of HPV used for?

The E “early” genes are transcribed shortly after basal keratinocytes are infected - E6 and E7 are the most important as inactivators

9

What phase do Rb and p53 act at?

G1-S Checkpoint

10

Why are HPVs 16, 18, 31 and 33 “high – risk”, while other HPVs are “low‐risk” for cancer?

They make E6 and E7 to inhibit tumor suppressor proteins

11

When will the HPV vaccine be ineffective?

Ineffective if patient already has CIN

12

Imiquimod MOA

Synthetic TLR7 agonist that induces proinflammatory cytokines, notably interferons, which attract antiviral effector cells to destroy warts

13

Cidofovir MOA

Cidofovir is a nucleoside analog that blocks DNA polymerases; standard use is to reduce herpes infections but topical cidofovir has been shown to reduce some HPV‐induced warts

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