Herpes I Flashcards Preview

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Flashcards in Herpes I Deck (21):
1

What kind of genetic material is in herpes viruses?

DNA

2

Are herpes viruses enveloped?

Yes

3

What is the acute infection caused by HSV Type I?

Cold Sores

4

What is the acute infection caused by HSV Type II?

Genital Herpes

5

What is the acute infection caused by Varicella-Zoster Virus (VZV)?

Chicken Pox

6

What is the acute infection caused by EBV?

Infectious Mononucleosis

7

What is the acute infection caused by HSV 6?

Roseola

8

What is the acute infection caused by HSV 7?

Roseola

9

What does the reactivation of VZV cause?

Shingles

10

Where does HSV Type I viral DNA reside latently?

Sensory cells of the trigeminal nerve ganglion

11

Where does viral DNA of HSV Type II reside?

Viral DNA resides in sensory cells of sacral ganglion

12

What drugs are used to treat HSV Type I and II?

Acyclovir and Priteliver

13

Acyclovir MOA

Aciclovir is converted by viral thymidine kinase to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP). ACV-TP, in turn, competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes

14

What viral enzyme is required for the function of acyclovir?

Viral thymidine kinase

15

Pritelivir MOA

Directed against herpesvirus helicase-primase inhibiting the formation of helices-primase and DNA replication

16

What is the initial VZV infection known as?

Varicella

17

What is the reactivation of VZV infection known as?

Zoster

18

What are some complications of varicella?

- Bacterial infection
- CNS manifestations
- Pneumonia (rare)

19

Wha type of vaccine is Varivax?

Live-attenuated virus

20

Where does latent VZV reside?

Doral root ganglion

21

What can reduce incidence of herpes zoster in the elderly?

Immunization or re-vaccination with VZV

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