Flashcards in Herpes I Deck (21)
What kind of genetic material is in herpes viruses?
Are herpes viruses enveloped?
What is the acute infection caused by HSV Type I?
What is the acute infection caused by HSV Type II?
What is the acute infection caused by Varicella-Zoster Virus (VZV)?
What is the acute infection caused by EBV?
What is the acute infection caused by HSV 6?
What is the acute infection caused by HSV 7?
What does the reactivation of VZV cause?
Where does HSV Type I viral DNA reside latently?
Sensory cells of the trigeminal nerve ganglion
Where does viral DNA of HSV Type II reside?
Viral DNA resides in sensory cells of sacral ganglion
What drugs are used to treat HSV Type I and II?
Acyclovir and Priteliver
Aciclovir is converted by viral thymidine kinase to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP). ACV-TP, in turn, competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes
What viral enzyme is required for the function of acyclovir?
Viral thymidine kinase
Directed against herpesvirus helicase-primase inhibiting the formation of helices-primase and DNA replication
What is the initial VZV infection known as?
What is the reactivation of VZV infection known as?
What are some complications of varicella?
- Bacterial infection
- CNS manifestations
- Pneumonia (rare)
Wha type of vaccine is Varivax?
Where does latent VZV reside?
Doral root ganglion