Hepatic Viruses Flashcards Preview

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Flashcards in Hepatic Viruses Deck (24):
1

What is the genetic material in HBV?

Partially dsDNA virus

2

How does HBV replicate?

Replicates using reverse transcriptase

3

What is unique about the genome of HBV?

It has multiple reading frames where one reading frame encodes RT and another frame encodes surface antigens

4

What is the anti-viral therapy for HBV?

RT inhibitors that are used as mono therapy as resistance mutations lead to incapacitating mutations

5

What antigen indicates HBV infectiousness?

HBeAg

6

Is integration of HBV DNA required for infection?

No

7

Does HBsAg contain DNA?

No

8

What is the first Ab made against HBV?

Anti-HBc Ab

9

What is the order of Ab made against HBV?

1. Anti-HBc
2. Anti-HBe
3. Anti-HBs

10

What is the only Ab that will be present in chronic HBV infection?

Only anti-HBc Ab - no other Ab against HBV

11

What is the HBsAg window period?

A period where HBs antigen and antibody are both negative and is the time before Ab are formed

12

What will be the serology to an HBV vaccinated individual?

ONLY anti-HBs Ab are present

13

What is the HBV vaccine made from?

HBsAg subunit vaccine

14

What superinfection on HBV can increase likelihood of fulminant hepatitis?

Hepatitis D (Delta Agent)

15

What is HDV genetic material?

It is a viroid with circular single strand RNA and requires HBV - it gets encapsulated in HBsAg coat

16

What unique activity does HDV have?

Has ribozyme activity that cleaves and ligates RNA

17

How can you be protected from HDV?

Vaccination with HBV

18

What is the genetic material of HCV?

Positive strand RNA virus

19

What drugs can be used to "cure" HCV?

Direct Acting Antivirals

20

What is the most common result of HBV infection?

Resolution

21

What is the most common result of HCV infection?

Persistent infection that can be asymptomatic or present with chronic hepatitis

22

What are factors that will have slow rate of progression of HCV?

- Female
- Younger age at infection

23

What is used for HCV diagnosis?

RT-PCR with sequencing

24

What population does HEV have high mortality in?

Pregnant women

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