Neoplasia I Flashcards Preview

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Flashcards in Neoplasia I Deck (15):
1

What is a neoplasia and what is it made up of?

It is a new growth that is made of:
-Parenchyma
-Stroma

2

What part of the neoplasia determines the biologic behavior?

Parenchyma

3

What is the function of stroma for the neoplasia?

• Connective tissue, blood vessels, immune system cells
• “Support” growth and spread of neoplasm

4

What are -omas used to designate?

Benign tumors

5

What are -carcinomas used to designate?

Malignant epithelial tumors

6

Anaplasia

It is “backward differentiation” – loss of the structural and functional differentiation of the cells from which a neoplasm is derived

7

What is the N:C ratio?

Nuclear to cytoplasmic ratio.

Normal cells generally have a N:C ratio of 1:4 or 1:6. This ratio may approach 1:1 in malignant cells.

8

Dysplsia

Disorderly architecture and altered cytology of cells, principally found in epithelium. Result of mutations. Cells may have pleomorphism, hyperchromatic nuclei, high N:C ratios, disorderly maturation, mitoses above basal layer.

9

Does dysplasia penetrate the basement membrane?

No

10

What is it called when dysplastic cells involve the entire thickness of an epithelial surface?

Carcinoma in-situ

11

What happens to the N:C ratio in malignant cells?

It increases

12

Metastasis

Secondary implants of a malignant tumor that are discontinuous with the primary tumor and may be in remote tissues. Metastases identifies a neoplasm to be malignant more than any other attribute.

13

What are the 3 methods of metastasis?

a) Seeding within body cavities
b) Via lymphatics (lymphatic spread)
c) Via blood vessels (hematogenous spread)

14

What is the hallmark of malignancy?

Invasion

15

What are -sarcomas used to designate?

Malignant mesenchyme tumors

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