Flashcards in Neoplasia I Deck (15):
What is a neoplasia and what is it made up of?
It is a new growth that is made of:
What part of the neoplasia determines the biologic behavior?
What is the function of stroma for the neoplasia?
• Connective tissue, blood vessels, immune system cells
• “Support” growth and spread of neoplasm
What are -omas used to designate?
What are -carcinomas used to designate?
Malignant epithelial tumors
It is “backward differentiation” – loss of the structural and functional differentiation of the cells from which a neoplasm is derived
What is the N:C ratio?
Nuclear to cytoplasmic ratio.
Normal cells generally have a N:C ratio of 1:4 or 1:6. This ratio may approach 1:1 in malignant cells.
Disorderly architecture and altered cytology of cells, principally found in epithelium. Result of mutations. Cells may have pleomorphism, hyperchromatic nuclei, high N:C ratios, disorderly maturation, mitoses above basal layer.
Does dysplasia penetrate the basement membrane?
What is it called when dysplastic cells involve the entire thickness of an epithelial surface?
What happens to the N:C ratio in malignant cells?
Secondary implants of a malignant tumor that are discontinuous with the primary tumor and may be in remote tissues. Metastases identifies a neoplasm to be malignant more than any other attribute.
What are the 3 methods of metastasis?
a) Seeding within body cavities
b) Via lymphatics (lymphatic spread)
c) Via blood vessels (hematogenous spread)
What is the hallmark of malignancy?