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Flashcards in Antbiotics Pharm High Yield Deck (65):
1

AE of penicillin G and V?

hemolytic anemia

2

Name the penicillinase sensitive penicillins? (4)

Amoxicillin
Ampicillin
Penicillin G and V
Piperacillin/ ticarcillin

3

Name the antipsuedomonal penicillins?

Piperacillin and ticaricillin

4

Which 2 classes of antibiotics block the 30S subunit of bacterial ribosomes?

Aminoglycosides (Gentamicin, neomycin, streptomycin)

Tetracyclines

5

What 5 classes of antibiotics bond the 50S bacterial ribosomal subunit?

Chlorampenicol

Clindamycin

Linezolid

Macrolides

Streptogramins

6

What antibiotic inhibits mRNA synthesis?

Rifampin

7

Which antibiotics are folic acid synthesis inhibitors?

Sulfonomides and Tromephoprim

8

Which antibiotics are DNA topoisomerase inhibitors?

Fluoroquinolones

9

What can Amoxicillin and ampicillin be used on?

HHELPS

HHELPS:

H. influenzae
E. coli
Listeria monocytogenes
Proteus mirabilis
Shigella

10

Narrow spectrum penicillins that are penicillinase resistant?

Dicloxacillin, nafcillin, oxacillin

11

AE of narrow spectrum penicillins?

Interstitial nephritis, hepatic metabolism

12

Function of clavulanic acid, sulbactam and tazobactum?

Beta lactamase inhibitors

13

Use of 1st generation cephalosporins?

PEcK: Proteus, E. coli, and Klebsiella

14

Use of 2nd generation cephalosporins?

HEN PEck:

H. flu, enterobacter, Neisseria

Proteus, E. coli, and Klebsiella

15

Which cephalosporin can be used for pseudomonase?

Ceftazidime (3rd generation)

16

What are the 3 main diseases that ceftriazone is used for?

Meningitis

Gonorrhea

Disseminated Lyme Disease

17

What are the AE of cephalosporins?

Disulfram like

Hemolytic anemia (coombs +)

increase nephrotoxcity of aminoglycosides

18

Which carbepenem is broad spectrum beta lactamase?

Imipenem

19

What are carbapenems ALWAYS administered wit?

cilastatin--> inhibitor or renal dehydropeptidase I to decrease inactivation of drug in renal tubules

20

AE of carbepenems?

Skin rash and sseizures

21

What is aztreonam used for?

Gram (-) rods only!!!

22

What class of antibiotics is aztreonam synergistic with?

Aminoglycosides

23

What type of bugs dose vancomycin work on?

Gram (+) ONLY!!!

24

3 major AE of vancomycin?

NOT

Nephrotoxicity
Ototoxicity
Thrombophlebitis

diffuse flushing (redman syndrome)

25

Which antibiotic inhibits tRNA binding at the A site?

Tetracyclines

26

Which antibiotics (2) lead to inhibition of translocation?

Macrolides and clindamycin

50S

27

Which antibiotic blocks peptidyl transferase?

Chloramphenicol (50S)

28

What is required for aminoglycosides to work?

O2

29

What are aminoglycosides used for?

Gram negative rod infections!!

30

AE of aminoglycosides?

Nephrotoxicity, neuromuscilar blockade, ototoxicity, teratogen

31

Mechanism of resistance to aminoglycosides?

acetylation, phosphorylation, pr adenulation

32

AE of tetracyclines?

Discoloration of teeth, inhibition of bone growth, photosensitivity

33

Mechanism of resistance to tetracyclines?

decreased uptake or increased efflux

34

What is chloramphenicol used to treat?

H. influenzae, N. meningitidis, S. pneumoniae, Rickettsia rickettsii

35

Which drug causes gray baby syndrome?

chlormaphenicol

36

What is clindamycin used for?

anaerobic infection in aspiration pneumonias, lung abscesses, and oral infections

37

Major AE associated with clindmycin?

C. diff colitis

38

What are linezolid and tedizolid used for?

MRSA and VRE (GRAM + Only)

39

What are the AEs of linezolid and tedizolid?

serotonin syndrome, BMS

40

What do macrolides treat?

atypical pneumonias, chlamydia, B. pertussis

41

AE of macrolides?

GI motility issues, prolonged QT interval

42

Which AIDS illnesses can be prophylazed with trimethoprim?

Pneumocystis jirovecii and toxoplasmosis

43

AE of trimethoprim?

Megaloblastic anemia and granulocytopenia

44

What do sulfonamdes treat?

nocardia, gram +, gram -, chlamydia

45

AE of sulfonamides?

Hypersensitivity reaction, hemolysis (G6PD deficient), nephrotoxicity, photosensitivity

46

AE of sulfonamides?

Hypersensitivity reaction, hemolysis (G6PD deficient), nephrotoxicity, photosensitivity

47

What are the respiratory flruoroquinolones?

Levofloxacin and moxifloxacin

48

What do fluoroquinolones treat?

Gram (-) rods of urinary and GI tracts (Pseudomonase, neisseria) and S. pneumo

49

"lipopeptide that disrupts cell membrane of gram positive cocci"

Daptomycin

50

Why can daptomycin NOT be used in respiratory infections?

inactivated by surfactant

51

Why can daptomycin NOT be used in respiratory infections?

inactivated by surfactant

52

AE of metronidazole?

Disulfram like reaction, HA, metallic taste

53

AE of metronidazole?

Disulfram like reaction, HA, metallic taste

54

DOC for pseudomonas?

Piperacillin and ticarcillin

55

Which drugs treats anaerobic infections above the diaphragm?

Clindamycin

56

What drug treats anaerobic infections below the diaphragm?

Metronidazole

57

Which drug inhibits proteins synthesis by binding to 50S subunit and preventing formation of the initiation complex?

Linezolid

58

"inhibit protein synthesis by blocking translocation"

macrolide

59

"inhibit bacterial dihydrofolate reductase"

trimethoprime

60

"inhibit folate synthesis via inhibition of dihydropteroate synthase"

sulfonamides

61

What can fluoroqinonoles NOT be taken with?

antacids

62

Which antibiotic can cause tendon rupture in people over 60yo?

fluoroquinolones

63

What is the mechanism of resistance to fluoroquinoloes?

chromosome encoded mutation in DNA gyrase

Plasmid mediated resistance

Efflux pumps

64

What are the AE of daptomycin?

Myopathy
Rhabdomyolysis

65

What is the mechanism of metronidazole?

forms toxic free radical metabolites in the bacterial cell that damage DNA

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