Endocrine Pharm High Yield Flashcards Preview

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Flashcards in Endocrine Pharm High Yield Deck (31):
1

Which 2 oral glucose medications work synergistically?

metformin and sulfonylureas

2

What are the 2 main AE of metformin?

lactic acidosis and GI upset

3

Name the class:

Chlorpropamide
Tolbutamide

1st generation sulfonylureas

4

Name the class:

Glipizide
Glimepride
Glyburide

2nd Generation sulfonylureas

5

Main AE of the ALL sulfonylureas?

Hypoglycemia
Weight gain

6

Specific AE to chlorpropamide and tolbutamate?

Disulfram like reaction

7

Which sulfonylureas should be avoided in hepatic dysfunction?

glipizide

8

Which sulfonylureas should not be used in renal failure?

ALL of them!!

9

Which oral hypoglycemics inhibit intestinal brush border alpha glucosidases?

alpha glucosidase inhibitors

Acarbose and miglitol

10

Main AE of acarbose and miglitol?

GI/ Diarrhea/ Flatulence

Hepatotox

11

Which oral hypoglucemics bind PPAR gtranscription regulator to increase insulin sensitivity?

Pioglitazone

Rosiglitazone

12

What are the main AE of pioglitazone and rosglitazone?

Weight gain, hepatotox, risk of fractures, heart failure and edema

13

What are the GLP 1 analogs?

Exenatide

Liraglitide

14

How do Exenatide and liraglitide work?

increase insulin and decrease glucacon

15

Major AE of exenatide and liraglitide?

N/V and pancreatitis

16

Name the DPP-4 inhibitors?

Linagliptin

Saxagliptin

Sigagliptin

17

How doe DPP-4 inhibitors work?

Prevent the breakdown of GLP-1

18

Which oral hypoglycemic is an amylin analog?

pramlintide

19

Which oral hypoglucemic is an SGLT2 inhibitor that blocks the reabsorption of glucose in the PCT?

Canagliflozin

20

AE of canagliflozin?

glycosuria and UTIs

21

What is thyroid medication can also block peripheral conversion of T4--> T3? How does it do this?

Propylthiouracil

It blocks 5- deiodinase

22

Which thyroid med can be used in pregnancy?

propylthiouracil

23

AE of propylothiouracil and methimazole?

skin rash
Agranulocytosis (P>M)
aplastic anemia
Hepatotoxicity (P)

24

What are conivaptan and Tolvaptan?

ADH antagonist

25

What is GH used in?

GH deficiency and turner syndrome

26

What s somatostatin used to treat?

acromegaly, carcinoid syndrome gastrinoma glucagonoma, esophageal varices

27

What is demeclocycline and what is it used to treat?

ADH antagonist and it is used to treat SIADH

28

What are the possible AE of demeclocycline?

nephrogenic DI, photosensitivity, abnormailites of bone and teeth

29

Which glucocorticoud has both muneralcorticoid and glucocorticoid activity?

fludrocortisone

30

What is cinacalcet?

Sensitizes Ca sensing receptors in PTH gland to circulating Ca in order to decrease PTH

31

AE of cinacalcet?

Hypocalcemia

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