GI Pharm High Yield Flashcards Preview

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Flashcards in GI Pharm High Yield Deck (22):
1

Name the class:

Cimetidine
Ranitidine
Famotidine

H2 Blocler

2

Does cimetidine induce or inhibit P450?

Inhibit!!!!

3

AE of H2 blockers?

antiandrogenic effects, cross BBB to cause confusion/ dizzy

4

Which H2 blockers should not be used in renal dysfunction?

Cimitidine and ranitidine

5

Name the class:

Omeprazone
lansoprzole
esomeprazole

PPI

6

Are PPI's reversible or irreversible?

irreversible

7

AE of PPI's?

C. diff, pneumonia, decrease serum Mg2+

8

Mechanism of bismuth sucralfate?

bind to ulcer base and provide protection

allow HCO3 secretion to reestablish pH gradient in the mucous layer

9

PGE1 analog?

misoprostol

10

Who is misoprostol contraindicated in?

women of childbearing potential (antiabortive)

11

Mechanism of octreotide?

long acting somatostatin analog

12

What metabolic imbalance can ALL antacids cause?

hypokalemia

13

Name the class:

Magnesium hydroxide
Magnesium citrate
Polyethylene glycol
Lactulose

Osmotic laxatives

14

Name the class:

Aluminum hydroxide
calcium carbonate
Magnesium hydroxide

Antacids

15

AE of calcium carbonate?

Hypercalcemia and rebound acid increase

16

Dx used to treat hepatic encephalopathy?

Lactulose--> promotes the excretion of NH4+

17

What is Sulfasalazine?

combo of sulfapyridine (antibacterial) and 5- aminosalicylic acid (anti inflammatory)

18

What is sulfasalazine used for?

UC, CD

19

Mechanism of ondansetron?

5HT3 antagonist--> decrease vagal stimulation--> anti-emetic properties

20

AE of ondansetron?

HA, constipation, QT interval prolongation

21

Name the mechanism?

Metoclopramde

D2 receptor antagonist--> increase resting tone of LES and promote motility

22

AE of metoclopramide?

TD, parkinson effects

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