Immunosuppressants High Yield Flashcards Preview

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Flashcards in Immunosuppressants High Yield Deck (52):
1

"blocks T cell activation by preventing I:-2 transcription"

Cyclosporine and Tacrolimus

2

AE of cyclosporine?

Nephrotoxicity

3

"inhibits mTOR to block T cell activation and B cell differentiation by preventing response to IL-2"

Sirolimus

4

What are the main AE of sirolimus?

Anemia, thrombocytopenia, leukopenia, insulin resistance

5

"monoclonal antibodies that block IL-2 receptor"

Daclizumab and Basiliximab

6

What is sirolimus used for?

Kidney transplant rejection prophylaxis

7

What is daclizumab/ baslizimab used for?

Kidney transplant rejection prophylaxis

8

"antimetabolite of 6-MP leading to inibition of lymphocyte proliferation by blocking nucleotide synthesis"

Azathioprine

9

AE of Azathrioprine?

Pancytopenia

10

What can increase the toxicity of azathrioprine?

allopurinol (because it inhibits XO needed for 6-MP degredation)

11

"inhibits NF-kappa B to suppress both B and T cell function by decreasing suppression of cytokines"

Glucocorticoids

12

What immunosuppressant can be used to treat:

Psoriasis

Cyclosporine

13

What immunosuppressant can be used to treat:

Rheumatoid arthritis

Azathriopine

14

What immunosuppressant can be used to treat:

Crohn disease

Azathrioprine

15

What immunosuppressant can be used to treat:

Glomerulonephritis

Azathrioprine

16

What immunosuppressant can be used to treat

Transplant rejection prophylaxis

Cyclosporine, tacrolimus, Azathrioprine, glucocoricoids

17

What is Aldesleukin used for?

RCC

Metastatic carcinoma

18

What is epoitin alfa used to treat?

Anemia (it is EPO)

19

What is filgrastim?

G-CSF

20

What is filgrastim used for?

recovery of bone marrow

21

What is sargramostim?

GM- CSF

22

What is sargramostim used for?

Recovery of bone marrow

23

What is IFN alpha used to treat?

Hep B
Hep C
Kaposi sarcoma
Malignant melanoma

24

What is IFN beta used to treat?

Multiple sclerosis

25

What is IFN gamma used to treat?

Chronic granulomatous disease

26

What is oprelvekin?

IL-11

27

What is oprelvekin used to treat?

Thrombcytopenia

28

What does alemtuzumab target?

CD52

29

What is alemtuzumab used for?

CLL

30

What does bevacizumab target?

VEGF

31

What is bevacizumab used to treat?

Colorectal cancer
RCC

32

What does cetuximab target?

EGFR

33

What does cetuximab treat?

IV breast colorectal cancer
Head and neck cancer

34

What does rituximab target?

CD 20

35

What does rituximab treat?

B cell non hodgkin lymphoma
CLL
RA
ITP

36

What does trastuzumab target?

HER2/neu

37

What does trastuzumab treat?

Breast cancer

38

What does adalimumab/ infliximab target?

soluble TNF- alpha

39

What is the use of adalimumab/ infliximab?

IBS
RA
Anklyosing spondylitis
Psoriasis

40

What does eculizumab target?

complement protein C5

41

What does eculizumab treat?

paroxysmal nocturnal hemoglobiunuria

42

What does Natalizumab target?

alpha4- integrin

43

What does natalizumab treat?

Multiple sclerosis

Crohn disease

44

Wat does abciximab taret?

platelet glycoproteins IIb/ IIIa

45

What does denosumab target?

RANKL

46

What is denosumab used to treat?

osteoporisis

47

What does omalizumab target?

IgE

48

What does omalizumab treat?

allergic asthma

(prevents IgE binding to Fc- epsilon-RI

49

What does palivizumab target?

RSV F protein

50

What does Palivizumab treat?

RSV prophylaxis for high risk infants

51

What does ranibizumab target?

VEGF

52

What does ranibizumab treat?

Neobascularization age related macular degeneration

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