Renal Pharm High Yield Flashcards Preview

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Flashcards in Renal Pharm High Yield Deck (33):
1

Diuretic used for elevated ICP/ IOP?

Mannitol

2

What are AEs of mannitol/

Pulmonary edema and dehydration

3

What is mannitol contraindicated in?

Heart failure

4

"diuretic that causes self limited NaHCO3 diuresis and decreased total body HCO3 stores"

Acetazolamide

5

What is the AE of acetazolamide?

Metabolic acidosis, hyperchloremia, NH3 toxicity, Sulfa allergy

6

What diuretic is used to treat altitude sickness?

Acetazolamide

7

What diuretic can treat glaucoma?

Acetazolamide

8

Name the class:

Furosemide
Bumetanide
Torsemide

Loop diuretics

9

What transport system do loop diuretics inhibit?

Na/ K/ 2Cl in TAL

10

How do loop diuretics effect the concentration of urine?

abolish hypertonicity of medulla (preventing concentratoin of urine)

11

What is the DOC for acute edematous states (like HF, cirrhosis, nephrotic syndrome, pulm edema)?

Loop diuretics

12

What are 4 major AEs of loop diuretics?

1- Ototoxicity
2- Hypokalemia
3- Gout
4- Nephritis (interstitial)

ALSO SULF ALLERGY

13

What is the mechanism of ethacrynic acid?

Loop diuretic that is not a sulfonamide!

14

What is the class:

Chlorthalidone
Hydrochlorothiazide

Thiazide diuretics

15

What transporter do thiazide diuretics inhibit?

NaCl reabsorption in the DCT (to decrease diluting capacity of the nephron)

16

What are the major AEs of thiazide diuretics?

1- Hypokalemia
2- metabolic alkalosis
3- hyperglycemia
4- hyperlipidemia
5- hypercalcemia
6- hyperuricemia

17

Which diuretic is used for idiopathic hypercalciuria (kidney stones)?

Thiazide diuretics

18

Aldosterone receptor antagonists in cortical collecting tubule?

Spironolactine and eplerenone (K sparing diuretics)

19

Which diuretics act in the cortical collecting tubule to block Na channels?

Triamterene and amiloride (K sparing diuretics)

20

What diuretics are used for hyperaldosteronism?

K+ sparing (spironolactone and amiloride)

21

What are the AE of spironolactone?

gynecomastia, anti androgen effects

22

With which diuretic does urinary NaCl decrease?

Acetazolemide

23

With which diuretics does Urine K increase?

Loop and thiazide

24

With which diuretic does blood pH decrease?

Acetazolamide (by dereasing HCO3 reab)

K sparing (by preventing K+/ H+ secretion

25

Which causes an increase in urinary Ca?

Loop

26

Which causes a decrease in urinary Ca?

thiazidess

27

How doe ACEi cause a decrease in blood pressure?

Decrease AT II--> deccrease GFR by preventing constriction of efferent arterioles

28

What are the AEs of ACEi?

Cough
Angioedema
Teratogen
increased creatinine
Hyperkalemia
Hypotension

29

What conditions are ACEi contraindicated in?

Bilateral RAS

30

"selectively block binding of angiotensin II to AT1 receptor"

ARB (losartan...)

31

What are the AE of ARBs?

Hyperkalemia
Decreased renal function
Hypotension
Teratogen

32

"direct renin inhibitor, blocks conversion of angiotensinogen to angiotensin I"

Aliskiren

33

What are the AEs of aliskiren?

hyperkalemia, decreased renal function, hypotension

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