Flashcards in Dermatology High Yield Deck (65)
What are the layer os the epidermis from surface to base?
"felt connecting ACTIN cytoskeletos of adjacent cells with Cadherins"
Tight junctions/ Zonula aderins
"structural support via KERATIN interactions"
Desmosome/ Macula adherens
"channel proteins called connexons permit electrical and chemical communication between cells"
"connects keratin in basal cells to underlying basement membranes"
What cell junction is targeted in Bullous pemphigoides?
What cell junction is targeted in pemphigus vulgaris?
"prevents paracellular movement of solutes; composed of claudins and occludins"
"flat lesion with well circumscribed change in skin color"
"elevated solid skin lesion
"small fluid containing blister
"large fluid containing blister >1cm"
"vesicles containing pus"
"transient smooth papule or plaque"
"flaking off of stratum corneum"
Scale--> eczema, psoriasis, SCC
What is hyperkeratosis?
increased thickness of stratum corneum
What is parakeratosis?
hyperkeratosis with retention of nuclei in statum corneum
What is spongiosis?
epidermal accumulation of edematous fluid in intercellular spaces
What is acantholysis?
separation of epidermal cells
What is Acanthosis?
What is an example of acanthosis?
"normal melanocyte number with decreased melanin production"
What is deficient or defective in albinism?
"hyperpigmentation associated with pregnancy"
"irregular areas of complete depigmentation"
What causes vitiligo?
Autoimmune destruction of melanocytes
What type of hypersensitivity is atopic dermatitis (eczema)?
"intradermal nevi vs junctional nevi"
What epidermal layer is increased in psoriasis and which is decreased?
what is Auspitz sign?
pinpoint bleeding spots from exposure of dermal papillae when scales are scraped off
"inflammatory facial skin disorder characterized by erythematous papules and pustules"
"flat, greasy, pigmented squamous epithelial proliferatoin with keratin filled cysts"
What is leser trelat sign?
sudden appearance of multiple suborrheic keratosis indicating an underlying malignancy
Bollous impetigo is associated with which type of infectious agent?
Common causes of cellulitis?
Infection involving the upper dermis and superficial lymphatics?
Most common cause of abscesses?
What are bacterial causes of necrotizing fasciitis?
What causes scalded skin syndrome?
Exotoxin destroys keratinocyte attachements in stratum granulosum
What type of antibody is seen in pemphigus vulgaris?
IgG antibody against desmoglein
Which blistering skin disorder has separation of epidermis?
Which blistering skin disorder has tense blisters?
Which blistering condition is more severe?
What skin disease is associated with celiac disease?
What is dermatitis herpetiforms?
IgA at tips of dermal papillae
"fever, bullae formation and necrosis, sloughing of skin, high mortality rate"
Stevens johnson reaction
what is acanthosis nigricans associated with?
hyperinsulinemia ad visceral malignany
"premalignant lesions caused by sun exposure?
"painful inflammatory lesions on subcutaneous fat, usually on anterior skins"
What conditions are associated with erythema nodosum?
"sawtooth infiltrate of lymphocytes at dermal- epidermal junction"
What are the 6 P's of lichen planus?
What type of rays from the sun are associated with tanning? With sunburn?
"pink pearly nodules with telangiectasias and rolled borders and central/ crusting ulceration"
basal cell carcinoma
What is the histological feature of basal cell carcinoma?
What is the mosts common skin cancer?
What type of exposures can lead to SCC of the skin?
Arsenic, sunlight and immunosuppression
What is the precursor to SCC?
What is the SCC varient that grows VERY quickly but then can regress over the course of months?
Tumor marker for melanoma/
What is the ABCDE of melanoma?
Evolution over time