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Flashcards in Rapid Review High Yield Deck (83):
1

"adrenal hemorrhage, hypotension, DIC"

Waterhouse Friedrichsen syndrome

2

"anaphylaxis following blood transfusion"

IgA deficiency

3

"Arachnodactyly, les=ns discoloration, aortic dissetion, hyperflexible joints"

marfan syndrome

4

"bilateral acoustic schwannomas"

NF2

5

"bilateral adenopathy, uveitis"

Sarcoidosis (nocaseating granulomas)

6

"bluish line on gingiva"

Burton line (lead poisoning)

7

"bone pain, bone enlargement, arthritis"

paget disease of the bone

8

"bounding pulses, diastolic murmur, head bobbing"

aortic regurgitation

9

"cafe-au-lait spots (unilateral), polystotic fibrous dysplasia, precocious puberty, multiple endocrine abnormalities"

McCune- Albright syndrome (mosaic G proteins signaling mutation)

10

What type of mutation is DMD?

X linked recessive fraeshift mutation of dystrophic gene

11

"cervical LAD, desquamating rash, coronary aneurysms, red conjunctiva and tongue:"

Kawasaki disease (treat with IVIG and aspirin)

12

"chest pain pericardial effusion/ friction rub, persistent fever following MI"

Dressler syndrome (autoimmune mediated post MI fibrinous pericarditis, 2-12 weeks after acute episode)

13

"chest pain with ST depressions on EKG"

Unstable angina (troponin -)

NSTEMI (toponin +)

14

"chorea, dementia, caudate degeneration"

Huntingtons disease--> CAG repeat expansion

15

What enzyme is deficient in McArdle disease?

Skeletal muscle glycogen phosphorylase deficeiccny

16

"conjugate horozontal gaze palsy, horizontal diplopia"

Internuclear opthalmoplegia (damage to MLF--> may be unilateral or bilateral

17

"deep, labored breathing/ hyperventilation"

Kussmaul respiration (diabetic ketoacidosis)

18

"type V collagen defect or type III collagen defect"

Ehlers- Danlos sndrome

19

"episodic vertigo, tinnitis, hearing loss"

Meniere disease

20

"erythroderma, LAD, hepatosplenomegaly, atypical T cells"

Mycosis fungoides (cutaenous T- cell lymphoma)

Sezary syndrome (mycosis fungoides + malignant T cells in blood)

21

"fever, night sweats, weight loss"

B symptoms (staging) of lymphoma

22

"fibrous plaques in soft tissue of penis with abnormal curvature"

Peyronie disease (connective tissue disorder)

23

"hamartous GI polyps, hyperpigmentation of mouth/ hands/ feet/ genitalia"

Peutz- Jeghers syndrome

(inherited, benign polyposis that can cause bowel obstruction and increase risk of GI cancer)

24

"hepatosplenomegaly, pancytopenia, osteoporosis, aspetic necrosis of femur, bone crisis"

Gaucher disease (glucocerebrosidase deficiency)

25

"hereditary nephritis, sensorineuronal hearing loss, cataracts"

Alport syndrome

26

"hyperphagia, hypersexuality, hyperorality hyperdocility"

Kluver- Bucy syndrome (bilateral amygdala lesion)

27

"hypoxemia, polycythemia, hypercapnia"

"blue bloater" (chronic bronchitis; hyperplasia of mucous cells)

28

"indurated, ulcerated genital lesion"

Nonpainful--> syphilis (primary)

Painful--> hancroid (H. ducreyi)

29

"infant with cleft lip/ cleft palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia"

Patau syndrome (trisomy 13)

30

"Infant with hypoglycemia, hepatomegaly--> 2 different diseases"

Cori disease (debranching enzyme deficiency)

Von Gierke disease (G6Pase deficiecy, more severe)

31

"infant with microcephaly rocker-bottom feet, clenched hands, and structural heart defect"

Edwards Syndrome (Trisomy 18)

32

"lucid window after traumatic brain injury"

Epidural hemaatoma (middle meningeal artery rupture)

33

"mucosal bleeding and prolonged bleeding time"

Glanzmann thrombasthenia (defect in platelet aggregatino due to lack of GpIIa/ IIIa

34

"myopathy (infantile hypertrophic ardiomyopathy), exercise intolerance"

Pompe disease (lysosomal alpha 1,4 glucosidase deficiency)

35

"neonate with arm paralysis following difficult birth"

Erb- Duchenne palsy (superior trunk C5/C6 brachial plexus injury: "waiter's tip")

36

:nystagmus, scanning speech, bilateral internucelar ophthalmoglegia"

Multiple sclerosis

37

"painful, raised red lesions of pads of fingers/ toes"

Osler nodes (infective endocarditis, immune complex deposition)

38

"painless erythematous lesions on palms and soles"

Janeway lesions (infective endocarditis, septic emboli/ microabscesses)

39

"pruritic, purple, polygonal planar papules and plaques"

Lichen planus

40

3 causes of rash on palms and soles?

1- coxsackie A
2- secondary sphyilis
3- RMSF

41

"recurrent cold (noninflammed) absecesses, unusual eczema, high IgE"

Hyper- IgE syndrome (Job Syndrome: neutrophil chemotaxis abnormality)

42

"red currant jelly stools"

Acute mesenteric ischemia (adults), intussusception (children)

43

"retinal hemorrhages with pale centers"

Roth spots (bacterial endocarditis)

44

"smooth, moist, painless, wart-like white lesions on genitals"

Condylomata lata (secondary syphilis)

45

What are 2 causes of strawberry tongue"?

Scarlet fever
Kawasaki disease

46

"swollen, hard painful finger joints"

Osteoarthritis

47

"systolic ejection murmur (crescendo- decrescendo"

Aortic stenosis

48

"telangiecctasias, recurrent epistaxis, skin discoloration, AV malformations, Gi bleeding, hematuria"

Osler- Weber- Rendu Syndrome

49

"vascular birthmark (port-wine stain) of the face"

Nevus flammeus (benign, but associated withSturge- Weber Syndrome)

50

Anticentromere antibodies?

Scleroderma (CREST)

51

Anti- desmoglein (epithelial) antibodies?

Pemphigus vulgaris (blistering)

52

Anti- mitochondrial antibodies?

Priamry biliary cirrhosis

53

Antiplatelet antibodies?

Idiopathic thrombocytopenic purpura

54

Anti-topoisomerase antibodies?

Diffs=use systemic scleroderma

55

"azurophilic peroxidase (+) granules inclusions in granulocytes and myeloblasts"

Auer rods (AML especially the PML type)

56

"Bamboo spine" on x-ray

Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)

57

"Basophilic stippling of RBCs"

Lead poisoning or sideroblastic anemia

58

"circular grouping of dark tumor cells surroudning pale neurofibrils"

Homer- Wright Rosettes

59

"degeneration of dorsal column fibers"

Tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns, lateral corticospinal, spinocerebellar tracts affected)

60

"delta wave" on EKG, short PR interval, supraventricular tachycardia

Wolf- Parkinson- White syndrome (Bundle of Kent bypasses AV node)

61

"desquamated epitheiul casts in sputum"

Curschmann spirals (bronchial asthma; can result in whorled mucous plug)

62

"electrical alternans (alternating amplitude on EKG)"

Pericardial tamponade

63

"enlarged cells with intranuclear inclusion bodies"

"owl eye" appearance of CMV

64

"enlarged thyroid cells with ground glass nuclei with central clearing"

"orphan annie" eyes nuclei (papillary carcinoma of the thyroid)

65

"eosinophilic inclusion bodies in cytoplasm of hippocamal and cerebellar neurons"

Negri bodies

66

"heart nodules (granulomatous)"

Aschoff bodies (rheumatic fever)

67

"hexagonal, double pointed, needle-like crystals in bronchial secretions"

Bronchial asthma (Charcot- Leyden Cysstals : eosinphilic granules)

68

"hypertension, hypokalemia, metabolic acidosis"

Conn Syndrome (primary hyperaldosteronism)

69

Intranuclear eosinophilic droplet- like bodies

Cowdry type A bodies (HSV or VZV)

70

"large granules in phagocytes, immunodeficiency"

Chediak- Higashi disease (congenital failure of phagolysosome formation)

71

"mammary gland (blue domed) cyst"

Fibrocystic change of the breast

72

"onion skin" periosteal reaction

Ewing sarcoma (malignant small blue cell tumor)

73

Cancers associated with Psammoma bodies?

Meningiomas, Papillary thyroid carcinoma, mesothelioma, papillary serious carcinoma of the endometrium and ovary

74

"pseudopalisading tumor cells on brain biopsy"

Glioblastoma multiforme

75

"recurrent infections, eczema, thrombocytopenia"

Wiskott- Aldrich syndrome

76

"rib notching"

Coartication of the aorta

77

"soap bubble" in femur or tibia on x ray

Giant cell tumor of bone (generally benign)

78

"steeple" sign on CXR

Croup (parainfluenza virus)

79

"thumb sign" on lateral neck xray?

Epiglottitis (H. influenzae)

80

"thyroid like appearance of kidney"

Chronic pyelonephritis (usually due to recurrent infections)

81

"tram-track" appearance of capillary loops of glomerular basement membranes on light microscopy

Membranoproliferative glomerulonephritis

82

WBC casts in urine

Acute pyelonephritis

83

"smudge cells"

CLL

Decks in Step 1 Review Class (62):