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Flashcards in Resp Pharm High Yield Deck (23):
1

Name the class:

Loratadine
Fexofenadine
Desloratidine
Cetirizine

2nd generation H1 blocker

2

Name the class:

Diphenhydramine
Dimenhydrinate
Chlorphehydramine

1st generation H1 blockers

3

What are the H1 blockers used for?

Allergies

4

What is Gauifenesin?

Expectorant--> thins respiratory secretions

5

What is NAC?

Mucolytic (loosens mucus plugs in a paint with CF bu disrupting disulfide bonds)

6

What is dextromethorphan?

Antitussive (antagonizes NMDA glutamate receptors--> codeine analog)

7

What is the mechanism of pseudoephedrine and phenylephrine?

Alpha adrenergic agonists (as a nasal degongestant)

8

What is bosentan?

Endothelin receptor antagonist used to treat pulmonary HTN

9

What is the AE of bosentan?

Hepatotoxic

10

What are PDE-5 inhibitors used to treat?

ED
Pulm HTN

11

What 2 factors cause bronchosconstriction in asthma?

1- inflammatory process
2- Parasympathetic tone

12

Which beta 2 agonist is used for acute attacks?

albuterol

13

Which beta 2 antagonist is used for prophylaxis?

Salmeterol/ formoterol

14

What is 1st line therapy for chronic asthma?

Corticosteroids

15

What is the mechanism of ipratropium?

M blocker--> prevent bronchoconstriction

16

What is ipratropium used to treat?

COPD and asthma

17

Which drug is an inhibitor of 5- lipoygenase pathway?

Zileutron

18

What drugs block leukotriene receptors?

Montelukast
Zafirlukast

19

What is omalizumab?

monoclonal anti-IgE antibody

20

What is the mechanism of theophylline?

Causes bronchodilation by inhibiting phosphodiesterase leading to increased cAMP

21

What are the AE of theophylline?

Cardiotoxicity, neurotoxicity

22

What is used in aspirin induced asthma?

Montelukast, zafirlukast

23

What is used in allergic asthma resistant to inhaled steroids and long acting Beta 2 agonists?

Omalizumab

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