Flashcards in Repro Pharm High Yield Deck (33)
What is the mechanism of leuprolide?
GnRH analog with agnoist propertes when used in a pulsatile fashion
Antagonist properties when used in a continuous fashion
How is leuprolide used in prostate cancer?
Used in a a continuous manner to downregulate GnRH receptor in pituitary to decrase FSH and LF release)
What is an AE of leuprolide?
What is ethinyl estradiol?
What is DES?
What is mestranol?
What are the AEs of estrogens?
1- increased risk of endometrial cancer
2- Bleeding in postmenopausal women
3- increased risk of thrombi
Mechanism of cloniphene?
Antagonist at estrogen receptors in hypothalamus--> increased LH and FSH release--> stimulates ovulation
What is cloniphene used to treat?
How does tamoxifen work?
Antagonist at breast
Agonist at bone and uterus
What does raloxifene work?
Antagonist at breast and uterus
Agonist at bone
What are the possible AE of tamoxifen?
What is the primary use of raloxifene?
Does estrogen increase or decrease osteoclast activity?
What is the mechanism of anastrozole?
What is anastrozole used to treat?
ER positive breast cancer
What can progestins be used for?
1- oral contraceptives
2- endometrial cancer
3- abnormal uterine bleeding
What is the mechanism of mifepristone?
Competitive inhibitor of progestins at progesterone receptors
What is given with mifepristone for the termination of a pregnancy?
How do estrogen/ progestin oral contraceptives work?
Inhibit Lh/ FSH to prevent the estrogen surge--> no ovulation
Which drug causes thickening of cervical mucus thereby limiting access of sperm to uterus?
What is the mechanism of terbutaline?
beta 2 agonist to relax uterus and decrease contraction frequencyt during labor
What is the mechanism of danazol?
synthetic androgen that acts as a partial agonist at androgen receptors
What is danazol used for?
2- hereditary angioedema
Describe the levels of LDL and HDL in testosterone use?
Mechanism of finasteride?
5alpha reductase inhibitor?
What is the mechanism of flutamide?
Nonsteroidal competitive inhibitor at androgen receptors
What is flutamide used for?
What is the mechanism of ketoconazole?
inhibits steroid synthesis (inhibits 17, 20 desmolase)
What is the mechanism of spironolactone?
inhibits steroid binding, 17alpha hydroxylase and 17, 20- desmolase
What are ketoconazole and spironolactone used to treat?
PCOS (to reduce antiandrogen symptoms)
What is the mechanism of tamsulosin?
alpha 1 antagonist used to treat BPH by inhibiting smooth muscle contraction--> selective for alpha 1A, D receptors (found on prostate) vs vascular alpha 1B receptors