Repro Pharm High Yield Flashcards Preview

Step 1 Review > Repro Pharm High Yield > Flashcards

Flashcards in Repro Pharm High Yield Deck (33):
1

What is the mechanism of leuprolide?

GnRH analog with agnoist propertes when used in a pulsatile fashion

Antagonist properties when used in a continuous fashion

2

How is leuprolide used in prostate cancer?

Used in a a continuous manner to downregulate GnRH receptor in pituitary to decrase FSH and LF release)

3

What is an AE of leuprolide?

Antiandrogen

4

What is ethinyl estradiol?

estrogen

5

What is DES?

Estrogen

6

What is mestranol?

Estrogen

7

What are the AEs of estrogens?

1- increased risk of endometrial cancer
2- Bleeding in postmenopausal women
3- increased risk of thrombi

8

Mechanism of cloniphene?

Antagonist at estrogen receptors in hypothalamus--> increased LH and FSH release--> stimulates ovulation

9

What is cloniphene used to treat?

infertility

10

How does tamoxifen work?

Antagonist at breast

Agonist at bone and uterus

11

What does raloxifene work?

Antagonist at breast and uterus

Agonist at bone

12

What are the possible AE of tamoxifen?

Thrombolytic events

Endometrial cancer

13

What is the primary use of raloxifene?

treat osteoporiosis

14

Does estrogen increase or decrease osteoclast activity?

Decrease

15

What is the mechanism of anastrozole?

Aromatase inhibitor

16

What is anastrozole used to treat?

ER positive breast cancer

17

What can progestins be used for?

1- oral contraceptives
2- endometrial cancer
3- abnormal uterine bleeding

18

What is the mechanism of mifepristone?

Competitive inhibitor of progestins at progesterone receptors

19

What is given with mifepristone for the termination of a pregnancy?

Misorostol (PGE1)

20

How do estrogen/ progestin oral contraceptives work?

Inhibit Lh/ FSH to prevent the estrogen surge--> no ovulation

21

Which drug causes thickening of cervical mucus thereby limiting access of sperm to uterus?

Progestins

22

What is the mechanism of terbutaline?

beta 2 agonist to relax uterus and decrease contraction frequencyt during labor

23

What is the mechanism of danazol?

synthetic androgen that acts as a partial agonist at androgen receptors

24

What is danazol used for?

1- endometriosis
2- hereditary angioedema

25

Describe the levels of LDL and HDL in testosterone use?

Increased LDL

Decreased HDL

26

Mechanism of finasteride?

5alpha reductase inhibitor?

27

What is the mechanism of flutamide?

Nonsteroidal competitive inhibitor at androgen receptors

28

What is flutamide used for?

prostate carcinoma

29

What is the mechanism of ketoconazole?

inhibits steroid synthesis (inhibits 17, 20 desmolase)

30

What is the mechanism of spironolactone?

inhibits steroid binding, 17alpha hydroxylase and 17, 20- desmolase

31

What are ketoconazole and spironolactone used to treat?

PCOS (to reduce antiandrogen symptoms)

32

What is the mechanism of tamsulosin?

alpha 1 antagonist used to treat BPH by inhibiting smooth muscle contraction--> selective for alpha 1A, D receptors (found on prostate) vs vascular alpha 1B receptors

33

Name the mechanism:

Sildenafil
Vardenafil
Tadalafil

Inhibit PDE5--> increase cGMP--> smooth muscle relazton in corpus cavernosum--> erection

Decks in Step 1 Review Class (62):