Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Step 1 Review > Hem/ Onc Pharm High Yield > Flashcards

Hem/ Onc Pharm High Yield Flashcards

(65 cards)

Start Studying
1
Q

What is the antidote for heparin?

A

protamine sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What causes HIT during heparin dosing?

A

Antibodies to heparin complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Does LMWH favor IIa or Xa inhibition?

A

Xa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mechanism of argatroban?

A

IIa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mechanism of bivalirudin?

A

IIa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mechanism of dabigatran?

A

IIa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which is used in pregnancy…warfarin or heparin?

A

heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rapid reversal of warfarin?

A

FFP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which has shorter half life…protein C/S or Factor II, VII, IX, X?

A

Protein C/S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mechanism of Apixaban?

A

Direct Xa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Mechanism of rivaroxaban?

A

direct factor Xa inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mechanism of alteplase, reteplase, streptokinase and tenecteplase?

A

directly or indirectly aid conversion of plasminogen to plasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How does aspirin irreversibly inhibit COX?

A

Covalent acetylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T/F: the affect of aspirin lasts until new platelets can be made

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mechanism of clopidogrel?

A

ADP receptor inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mechanism of ticagrelor?

A

ADP receptor inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mechanism of ticlopidine?

A

ADP receptor inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Major AE of clopidogrel and ticagrelor and ticlopidine?

A

Neutropenia and TTP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Mechanism of cilostazol?

A

PDE III inhibitor–> increase cAMP in platelets–> no platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mechanism of dipyridamole?

A

PDE III inhibitor–> increase cAMP in platelets–> no platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Mechanism of Abiximab?

A

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Mechanism of eptifibatide?

A

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Mechanism of eptifibatide?

A

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

When part of the cell cycle does bleomycin act during?

A

G2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
When does Paclitaxel work?
M
26
When does 5-FU work?
S
27
When does 6-MP work?
S
28
When do carumsine and lomustine work?
G1/ G0
29
When do etoposide and teniposide work?
S and G2
30
Which 2 antineoplastic agents decrease thymidine synthesis?
Methotrexate and 5FU
31
Which antineoplastic agent decreases the synthesis of purines?
6-MP
32
Which antineoplastic agent inhibits ribonucleotide reductase?
hydroxyurea
33
Which antineoplastic agent breaks DNA strands?
Bleomycin
34
Which antineoplastic agents are DNA intercalators?
Dactinomycin and doxorubicin
35
Which antineoplastic agent inhibits top II?
etoposide/ tenoposide
36
Which antineoplastic agent inhibits top i?
irinotecan
37
What enzyme activates 6MP?
HPGRT
38
What is a prodrug of 6PM?
azathioprine
39
What is cladribine?
Purine analog used to treat hairy cell leukemia
40
What can increase the toxicity of 6MP?
allopurinol (because XO is inhibited)
41
What is cytarabine?
pyrimidine analog--> inhibit DNA polymerase
42
What enzyme does methotrexate inhibit?
dihydrofolate reductase
43
Major AEs of methotrexate?
Pulmonary fibrosis, myelosuppression, hepatotoxicity
44
Major AE of bleomycin?
pulmonary fibrosis
45
Major AE of doxorubicin?
cardiotoxicity (prevent with dexrazoxane)
46
Tx for Wilms tumor, Ewing sarcoma and rhabdo?
Dactinomycin
47
Mechanism of busulfan?
cross links DNA
48
What is busulfan used to treat?
CML (ablates bone marrow)
49
Mechanism of cyclophosphamide?
cross link DNA
50
What s a major AE of cyclophosphamide?
hemorrhagic cystitis (prevent with mesna)
51
Which alkylating agents can cross the BBB?
Carmustine , limustine
52
Which stabelizes MTs?
Paclitaxel
53
Which inhibits polymerization of MTs?
vincristine and vinblastine
54
Major AE of cisplatin?
nephrotoxicity and ototoxicity
55
Which glucocorticoid is used in cancer chemo?
prednisone
56
Mechanism of bevacizumab?
Monoclonal antibody against VEGF, inhibits angiogenesis
57
What is bevacizumab used for?
RCC and colorectal cancer
58
Mechanism of Erlotinib?
EGFR tyrosine kinase inhibitor
59
What is erlotinib used for?
Nonsmall cell lung cancer
60
Mechanism of imatinib?
tyrosine kinase inhibitor of BCR- ABL and c-kit
61
What is imatinib used for?
CML
62
Mechanism of rituximab?
monoclonal antibody against CD20
63
What is rituximab used for?
CLL, non hodgkin lymphoma
64
Mechanism of trastuzumab?
antibody against HER2 (a tyrosine kinase receptor)
65
AE of trastuzumab?
Cardiotoxicity

Step 1 Review (62 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions