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Flashcards in Hem/ Onc Pharm High Yield Deck (65)
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1

What is the antidote for heparin?

protamine sulfate

2

What causes HIT during heparin dosing?

Antibodies to heparin complex

3

Does LMWH favor IIa or Xa inhibition?

Xa

4

Mechanism of argatroban?

IIa inhibitor

5

Mechanism of bivalirudin?

IIa inhibitor

6

Mechanism of dabigatran?

IIa inhibitor

7

Which is used in pregnancy...warfarin or heparin?

heparin

8

Rapid reversal of warfarin?

FFP

9

Which has shorter half life...protein C/S or Factor II, VII, IX, X?

Protein C/S

10

Mechanism of Apixaban?

Direct Xa inhibitor

11

Mechanism of rivaroxaban?

direct factor Xa inhibitor

12

Mechanism of alteplase, reteplase, streptokinase and tenecteplase?

directly or indirectly aid conversion of plasminogen to plasmin

13

How does aspirin irreversibly inhibit COX?

Covalent acetylation

14

T/F: the affect of aspirin lasts until new platelets can be made

true

15

Mechanism of clopidogrel?

ADP receptor inhibitor

16

Mechanism of ticagrelor?

ADP receptor inhibitor

17

Mechanism of ticlopidine?

ADP receptor inhibitor

18

Major AE of clopidogrel and ticagrelor and ticlopidine?

Neutropenia and TTP

19

Mechanism of cilostazol?

PDE III inhibitor--> increase cAMP in platelets--> no platelet aggregation

20

Mechanism of dipyridamole?

PDE III inhibitor--> increase cAMP in platelets--> no platelet aggregation

21

Mechanism of Abiximab?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

22

Mechanism of eptifibatide?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

23

Mechanism of eptifibatide?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

24

When part of the cell cycle does bleomycin act during?

G2

25

When does Paclitaxel work?

M

26

When does 5-FU work?

S

27

When does 6-MP work?

S

28

When do carumsine and lomustine work?

G1/ G0

29

When do etoposide and teniposide work?

S and G2

30

Which 2 antineoplastic agents decrease thymidine synthesis?

Methotrexate and 5FU

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