Hem/ Onc Pharm High Yield Flashcards Preview

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Flashcards in Hem/ Onc Pharm High Yield Deck (65):
1

What is the antidote for heparin?

protamine sulfate

2

What causes HIT during heparin dosing?

Antibodies to heparin complex

3

Does LMWH favor IIa or Xa inhibition?

Xa

4

Mechanism of argatroban?

IIa inhibitor

5

Mechanism of bivalirudin?

IIa inhibitor

6

Mechanism of dabigatran?

IIa inhibitor

7

Which is used in pregnancy...warfarin or heparin?

heparin

8

Rapid reversal of warfarin?

FFP

9

Which has shorter half life...protein C/S or Factor II, VII, IX, X?

Protein C/S

10

Mechanism of Apixaban?

Direct Xa inhibitor

11

Mechanism of rivaroxaban?

direct factor Xa inhibitor

12

Mechanism of alteplase, reteplase, streptokinase and tenecteplase?

directly or indirectly aid conversion of plasminogen to plasmin

13

How does aspirin irreversibly inhibit COX?

Covalent acetylation

14

T/F: the affect of aspirin lasts until new platelets can be made

true

15

Mechanism of clopidogrel?

ADP receptor inhibitor

16

Mechanism of ticagrelor?

ADP receptor inhibitor

17

Mechanism of ticlopidine?

ADP receptor inhibitor

18

Major AE of clopidogrel and ticagrelor and ticlopidine?

Neutropenia and TTP

19

Mechanism of cilostazol?

PDE III inhibitor--> increase cAMP in platelets--> no platelet aggregation

20

Mechanism of dipyridamole?

PDE III inhibitor--> increase cAMP in platelets--> no platelet aggregation

21

Mechanism of Abiximab?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

22

Mechanism of eptifibatide?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

23

Mechanism of eptifibatide?

Bind to GpIIb/IIIa on activated platelets to prevent aggregation

24

When part of the cell cycle does bleomycin act during?

G2

25

When does Paclitaxel work?

M

26

When does 5-FU work?

S

27

When does 6-MP work?

S

28

When do carumsine and lomustine work?

G1/ G0

29

When do etoposide and teniposide work?

S and G2

30

Which 2 antineoplastic agents decrease thymidine synthesis?

Methotrexate and 5FU

31

Which antineoplastic agent decreases the synthesis of purines?

6-MP

32

Which antineoplastic agent inhibits ribonucleotide reductase?

hydroxyurea

33

Which antineoplastic agent breaks DNA strands?

Bleomycin

34

Which antineoplastic agents are DNA intercalators?

Dactinomycin and doxorubicin

35

Which antineoplastic agent inhibits top II?

etoposide/ tenoposide

36

Which antineoplastic agent inhibits top i?

irinotecan

37

What enzyme activates 6MP?

HPGRT

38

What is a prodrug of 6PM?

azathioprine

39

What is cladribine?

Purine analog used to treat hairy cell leukemia

40

What can increase the toxicity of 6MP?

allopurinol (because XO is inhibited)

41

What is cytarabine?

pyrimidine analog--> inhibit DNA polymerase

42

What enzyme does methotrexate inhibit?

dihydrofolate reductase

43

Major AEs of methotrexate?

Pulmonary fibrosis, myelosuppression, hepatotoxicity

44

Major AE of bleomycin?

pulmonary fibrosis

45

Major AE of doxorubicin?

cardiotoxicity (prevent with dexrazoxane)

46

Tx for Wilms tumor, Ewing sarcoma and rhabdo?

Dactinomycin

47

Mechanism of busulfan?

cross links DNA

48

What is busulfan used to treat?

CML (ablates bone marrow)

49

Mechanism of cyclophosphamide?

cross link DNA

50

What s a major AE of cyclophosphamide?

hemorrhagic cystitis (prevent with mesna)

51

Which alkylating agents can cross the BBB?

Carmustine , limustine

52

Which stabelizes MTs?

Paclitaxel

53

Which inhibits polymerization of MTs?

vincristine and vinblastine

54

Major AE of cisplatin?

nephrotoxicity and ototoxicity

55

Which glucocorticoid is used in cancer chemo?

prednisone

56

Mechanism of bevacizumab?

Monoclonal antibody against VEGF, inhibits angiogenesis

57

What is bevacizumab used for?

RCC and colorectal cancer

58

Mechanism of Erlotinib?

EGFR tyrosine kinase inhibitor

59

What is erlotinib used for?

Nonsmall cell lung cancer

60

Mechanism of imatinib?

tyrosine kinase inhibitor of BCR- ABL and c-kit

61

What is imatinib used for?

CML

62

Mechanism of rituximab?

monoclonal antibody against CD20

63

What is rituximab used for?

CLL, non hodgkin lymphoma

64

Mechanism of trastuzumab?

antibody against HER2 (a tyrosine kinase receptor)

65

AE of trastuzumab?

Cardiotoxicity

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