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Flashcards in MSK Pharm Deck (27):
1

What is the mechanism of zileutron?

Inhibits lipoxygenase to inhibit leukotriene synthesis

2

What is the mechanism of montelukast and zafirlukast?

leukortiene receptor antagonists

3

What is the function of LTB4?

Neutrophil chemotactic

4

What is the function of PGI2?

inhibits platelet aggregation and promotes vasodilation

5

What are the 2 functions of acetaminophen?

1- antipyretic
2- analgesic

NOT AN ANTI INFLAMMATORY

6

How does acetominophen cause hepatic necrosis?

Its metabolite (NAPQI) depletes glutathione and forms toxic byproducts in the liver

7

What regenerates glutathione?

NAC

8

Effect of low does aspirin?

decrease platelet aggregation

9

Effect of intermediate dose aspirin?

Antpyretic and analgesic

10

Effect of high dose aspirin?

Anti-inflammtory

11

What is an AE of celecoxib?

increased risk of thrombosis

Sulfa allergy

12

What is used to close a PDA?

Indomethican--> COX inhibitor to decreased PGE2

13

What are the AEs of NSAIDS?

nephritis
gastric ulcers
renal ishcemia (because no vasodilation of afferent arterioles)

14

What is the mechanism of bisphosphonates?

inhibit osteoclast activity

15

What is a possible AE of bisphosphonates?

corrosive esophagitis, osteonecrosis of the jaw

16

What is teriparatide?

recombinant PTH analog to increase osteoblastic activity

17

What is a possible AE for teriparatide?

Increased risk for osteosarcoma

18

What is the mechanism of allopurinol?

Inhibits XO

19

What is the mechanism of febuxostat?

inhibits XO

20

What is the mechanism of pegloticase?

recombinant uricase that catalyzes metabolism of uric acid to allantoin

21

What is the mecahnism of probenecid?

inhibits reabsorption of uric acid in PCT

22

What is an AE of probenecid?

can precipitate uric acid calculi

23

What drugs are used to treat gout acutely?

NSAIDS
Glucocorticoids
Colchicine

24

How does cochicine work?

Binds to and stabilizes tubulin to inhibit microtubule polymerization (impairing neutrophil chemotaxis and degranulation)

25

What is etanercept?

TNF alpha inhibitor

26

What is infliximab/ adalimumab?

TNF alpha inhibitor

27

What are the TNF alpha inhibitors used to treat?

RA, psoriasis, ankylosing spondylitis, IBD (infliximab)

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