Oncogenes and Tumor Suppressor Genes Flashcards Preview

Step 1 Review > Oncogenes and Tumor Suppressor Genes > Flashcards

Flashcards in Oncogenes and Tumor Suppressor Genes Deck (25):
1

Gene product? Associated Tumor?

BCR- ABL

Tyrosine Kinase

CML, ALL

2

Gene product? Associated Tumor?

BCL-2

Antiapoptotic molecule

Follicular and undifferentiated lymphomas

3

Gene product? Associated Tumor?

BRAF

Serine/ threonine kinase

Melanoma

4

Gene product? Associated Tumor?

c-kit

Cytokkine receptor

GIST (gastrointestinal stromal tumor)

5

Gene product? Associated Tumor?

c- myc

Transcription factor

Burkitt lymphoma

6

Gene product? Associated Tumor?

HER2/ neu

Tyrosine kinase

Breast, ovarian, and gastric carcinomas

7

Gene product? Associated Tumor?

L- myc

Transcription factor

Lung tumor

8

Gene product? Associated Tumor?

N- myc

Transcription factor


Neuroblastoma

9

Gene product? Associated Tumor?

RAS

GTPase

Colon cancer lung cancer, pancreatic cancer

10

Gene product? Associated Tumor?

RET

Tyrosine kinase

MEN 2A/ 2B

Medullary thyroid cancer

11

Gene product? Associated Tumor?

APC

No associated product

Colorectal cancer

12

Gene product? Associated Tumor?

BRAC1/ BRCA2

DNA repair protein

Breast cancer/ Ovarian cancer

13

Gene product? Associated Tumor?

DCC

Deleted in colon cancer (tumor suppressor gene)

Colon cancer

14

Gene product? Associated Tumor?

DPC4/ SMAD4

Deleted in pancreased cancer (tumor suppressor gene)

Pancreatic cancer

15

Gene product? Associated Tumor?

MEN1

Menin

MEN1

16

Gene product? Associated Tumor?

NF1

Ras GTPase activating protein (neurofibromin)

NF1

17

Gene product? Associated Tumor?

NF2

Merlin protein

NF2

18

Gene product? Associated Tumor?

p16

cyclin dependant kinase inhibitor 2A

Melanoma

19

Gene product? Associated Tumor?

p53

Transcription factor for p21, blocks G1--> S

most human cancers, Li- fraumeni syndrome

20

Gene product? Associated Tumor?

PTEN

seen in breast cancer, prostate cancer, and endometrial cancer

21

Gene product? Associated Tumor?

Rb

inhibits E2F; blocks G1--> S

retinoblastoma, osteosarcoma

22

Gene product? Associated Tumor?

TSC1

Hamartin protein (tumor suppressor)

tuberous sclerosis

23

Gene product? Associated Tumor?

TSC2

Tuberin protein (tumor suppressor)

Tuberous sclerosis

24

Gene product? Associated Tumor?

VHL

Inhibits hypoxia inducible factor 1a

VHL disease, RCC

25

Gene product? Associated Tumor?

WT1/ WT2

Tumor suppressor gene

wilms tumor (nephroblastoma)

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