Pathology of the Male GU II: Penis and Testes Flashcards Preview

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Flashcards in Pathology of the Male GU II: Penis and Testes Deck (38):
1

Hypospadias

Urethral opening on the ventral surface

2

Epispadias

Urethral opening on the dorsal surface

3

Phimosis

Prepuce cannot be retracted

4

Paraphimosis

Phimotic prepuce is forcibly retracted leading to pain and urinary retention

5

Reiter Syndrome

Combination of conjunctivitis, polyarthritis and genital infection often caused by Chlamydia trachomatis

6

Which HSV causes gingivostomatitis?

HSV-1

7

Which HSV causes genital herpes?

HSV-2

8

What are the histological signs of herpes infection?

Multinucleation - Margination - Molding

9

Condyloma Acuminatum

Genital wart caused by HPV-6 and 11

10

What are risk factors for SCC of the penis?

Poor hygiene and phimosis - accumulation of smegma, and history of genital warts.

11

Cryptorchidism

Undescended testis

12

What chromosome abnormality is cryptorchidism associated with?

Trisomy 13

13

Reiter Syndrome

Combination of conjunctivitis, polyarthritis and genital infection often caused by Chlamydia trachomatis

14

Seminoma

Localized to testis for long time and have little metastasis - very radiosensitive and have a good prognosis

15

What are risk factors for SCC of the penis?

Poor hygiene and phimosis - accumulation of smegma, and history of genital warts.

16

What will be seen on histology with cryptorchidism?

Testicular atrophy

17

Varicocele

Dilated veins in the spermatic cord with a "bag of worms" feeling

18

Testicular Torsion

Twisting of the cord with thick-walled arteries patent but the veins are blocked off leading to vascular engorgement and eventual infarction

19

What race are testicular tumors more common in?

Caucasians

20

Nonseminomatous GCTs

More aggressive than seminomas with hematogenous spread and are radio resistant but most can be cured with aggressive chemotherapy.

21

What is the risk for testicular cancer with cryptorchidism?

The higher the testis location, higher the risk of cancer - risk is greater in the right than the left

22

Is trauma a risk factor for testicular cancer?

NO

23

What is a chromosome found with invasive testicular tumors?

12i Chromosome

24

- Seen often associated with malignant germ cell tumors
- Intratubular proliferation of malignant germ cells
- Large atypical cells, abundant clear cytoplasm, central nucleus, prominent nucleoli “fried egg”

Intratubular Germ Cell Neoplasia

25

What is the most common germ cell tumor in males?

Seminoma

26

What can rarely be increased as a marker in seminomas?

beta-HCG

27

Embryonal Carcinoma

Large anaplastic cells with prominent nucleoli with indistinct cell borders arranged in solid, glandular, tubular, papillary patterns.

28

Yolk Sac Tumor

Most common testicular tumor in infants up to 3 yrs - reticular network of cuboidal cells, papillary and solid patterns (Schiller-Duval or glomeruloid bodies) and hyaline-like globules

29

Choriocarcinoma

Highly aggressive and invasive into the blood with beta-HCG as a marker

30

Teratoma

Always malignant in males - Random admixture of tissue derived from ectoderm, endoderm and mesoderm

31

Leydig Cell Tumor

- Most common sex-cord stroll tumor in males
- Usually unilateral
- Well circumscribed
- Crystalloids of Reinke

32

Lymphoma of the Testicle

Usually secondary. The most common - large B-cell lymphoma and is most commonly seen in patients greater than 60 yrs

33

Most common testicular tumor in adults?

Seminoma

34

Most common bilateral primary testicular tumor?

Seminoma

35

Most common bilateral testicular tumor?

Lymphoma

36

Most common testicular cancer in infants and children?

Yolk Sac Tumor

37

Most common nongerm cell tumor of the testis?

Leydig Cell Tumor

38

Which are more common in the testis - mixed tumors or pure histologic types of tumors?

Mixed

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