Systemic Viral Infection: Mumps, Measles, Rubella and PB19 Flashcards Preview

Pathology > Systemic Viral Infection: Mumps, Measles, Rubella and PB19 > Flashcards

Flashcards in Systemic Viral Infection: Mumps, Measles, Rubella and PB19 Deck (20):
1

Mumps

Acute viral illness that causes parotitis and can cause orchitis

2

How is mumps transmitted?

Respiratory droplets

3

What is the long term outcome of mumps?

Lifelong protective immunity

4

What are some of the systemic effects of mumps infection?

Can affect the pancreas, testes, ovaries, peripheral nerves, eye, inner ear and CNS.

5

What is the pathogenesis of mumps?

Infects epithelial cells of the respiratory tract and spreads via viremia leading to a systemic infection

6

What immunity is required for control of mumps?

Cell-mediated immunity is essential for control of infection and responsible for a portion of the symptoms. Antibody is not sufficient due to mumps’ ability to spread cell to cell.

7

What is the lab diagnosis for mumps done with?

Serology
- Positive serologic test for mumps IgM antibody
- Significant increase in mumps IgG Ab

8

Measles

Mild respiratory infection that spreads to cervical lymph nodes and viremia leads to fever and rash

9

What is a complication of measles?

Immunosuppression can lead to other infections being superimposed onto the measles infection

10

Koplik Spots

Salt like spots seen inside the oral mucosa diagnostic of measles

11

What patients are at increased risk of subacute sclerosing panencephalitis?

Younger patients. The younger they are, the greater the risk - especially infants

12

Rubella

AKA German measles and presents with a upper respiratory tract infection with a maculopapular rash

13

How is rubella diagnosed in the lab?

Serology

14

What is a high risk population for rubella?

Pregnant women

15

What can occur if a pregnant woman is infected with rubella?

- Congenital Rubella Syndrome
- Miscarriage
- Stillbirth

16

What are these symptoms associated with?
• Deafness
• Cataracts
• Heart defects
• Microcephaly
• Mental retardation
• Bone alterations
• Liver and spleen damage

Congenital Rubella Syndrome

17

What is "slapped cheek" syndrome a symptom of?

Parvovirus B19 infection

18

What is the pathogenesis of parvovirus B19 infection?

Infects mitotically active erythroid precursor cells in the bone marrow and establishes lytic infection

19

What is the risk for parvovirus B19 in pregnant women?

Virus can cross the placenta and infect the fetus leading to severe anemia that can lead to spontaneous abortion

20

What is erythema infectiousum AKA?

Fifth's Disease

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