Flashcards in Antimicrobials/ Antifungals/ Antivirals High Yield Deck (57):
Treatment for M. tuberculosis?
Treatment for M. avium- intracellulare?
Which drug inibits mycolic acid synthesis?
Which drug inhibits arabinoglycan synthesis?
Which drug inhibits DNA dependent RNA polymerase?
AE of rifampin?
Minor hepatotoxicity, and drug interactions (increase P450 activity)
How is isoniazid activated within cells?
Bacterial catalase peroxidase needed to convert INH to active metabolite
AE of isoniazid?
Neurotoxicity and hepatotoxicity
How does resistance to Isoniazid occur?
Underexpression of activating catalase peroxidase
AE of ethambutol?
Optic neuropathy (red green color blindness)
What is used for prevention of conococcal conjunctivitis in newborns?
5 drugs that can be used on MRSA?
2 drugs that work for VRE?
Streptogrammins (quinuprstin, dalfoprostin)
Drug that inhibits lanosterol synthesis via inhibition of squalene epoxide?
Drug that inhibits fungal cell wall synthesis via inhibition of Beta glucan?
Echinocandins (capsofungin, anidulafungin)
Drug that inhibits ergosterol synthesis via inhibtion of 14 alpha demethylase?
Azoles (Ketoconazole, fluconazole...)
Drug that inhibit fungal nucleic acid synthesis?
Drugs that form membrane pores in fungus?
(Amphoteracin B and nystatin)
AE of amphotericin B?
Renal tubular acidosis
What is flucytosine used for?
systemic fungal infections (combo with Ampho B)
AE of the azoles?
Inhibition of cyt P450! (Liver dysfunction
Which are the topical azoles?
Clotrimazole and miconazole
AE of terbifine?
GI upset, HA, hepatotoxicity
What is terbifine used for ?
What antifungal interferes with microtubule function, and disrupts mitosits"
What is griseofulvin used for?
oral treatment of superficial infections--> tinea!
AE of griseofulvin?
Teratogenic, carcinogenic, induce P450 system
What are the following drugs used for:
Permethrin (Na channel blocker)
Malathion (AChase inhibitor)
Lindane (Blocl GABA channels)
Anti-mite/ louse therapy
AE of chloroquine?
Inhibitors of inhluenza neuraminidase?
Oseltamvir and zanamivir
What drugs are guanosine anaolgs that are phosphorhylated by viral thymidine kinase in invected cells?
Acyclovir, famciclovir and valacyclovir
What is the mechanism of resistance to acyclovir and similar drugs?
mutated viral thymidine kinase
Which herpes virus antiviral can be used in CMV?
What is Foscarnet?
viral DNA/ RNA polymerase inhibitor and HIV reverse transcriptase inibitor
What is foscarnet used for?
CMV retinitis when gancyclovir fails and acyclovir resistant HSV
AE of foscarnet?
Nephrotoxicity and electrolyte abnormalities (hypo all except hyperphosphate)
Use and mechanism of cidofovir?
Same as foscarnet
Name the HIV protease inhibitors?
Which protease inhibitor is used as a "boost"?
Ritonavir...it inhibits P450
What are the major AE of Protease inhibitors?
Name the class:
Major AE of all NRTI's
AE of zidovudine?
Major AE of didanosine?
Name the class:
AE of NNRTI's?
Enfavirenz--> teratogenic and vivid dreams
Name the mechanism:
increase creatinine kinase
AE of raltegravir
Increased CK because Rhabdo
Name the mechanism:
Binds gp41 to inhibit fusion
Mechnaism of maraviroc?
Binds CCR5 to inhibit interaction with gpl120
What is IFN alpha used to treat?
Chronic Hep B/ C
Hairy cell leukemia
What is IFN- beta used to treat?
What is ITN- gamma used to treat?
Chronic granulomatous disease
What are ribavirin, simeprevir and sofosbuvir used to treat?
Which Hep C drug is a protease inhibitor?
Which hep C drug inhibits RNA dependent RNA polymease (acting as a chain terminator)?