Flashcards in 3/31 - UW 37 Deck (50)
What two reactions/enzymes reduce oxidative damage in RBCs?
G6PD and glutathione reductase
What drugs are purine analog antimetabolites?
What drugs are pyrimidine analog antimetabolites?
How does Cladribine achieve high intracellular concentrations? What is it used for?
Resistant to adenosine deaminase. Used for Hairy Cell Leukemia.
Where are Major Basic Proteins found?
In eosinophil granules, help defend against parasites
What type of colonic polyp can transform into malignant cancer?
Adenomatous polyps, especially VILLOUS (villain!)
What are the most common histologic features of Glioblastoma multiforme?
New vessel formation
Small round cells, bizarre giant cells, mitotic figures
Where is Glioblastoma multiforme most often found?
Butterfly distribution in the brain: Frontal and temporal lobes, crossing the midline
What is the cell of origin of Glioblastoma multiforme?
Transtentorial (uncal) herniation can compress which nerve?
What are the 3 Ds of Botulinum?
Diplopia, Dysphagia, Dysphonia
What is the most common cause of recurrent lobar hemorrhages in an elderly patient?
Cerebral amyloid angiopathy
Where are Charcot-Bouchard aneurysms typically found? In what patients?
In the arterioles of the basal ganglia, internal capsule, and deep white matter. In patients with long-standing hypertension
What is responsible for the green color of pus and sputum?
What are the cardiac anomalies seen in Turner patients?
Bicuspid aortic valve and aortic coarctation
When would you see pulsus paradoxus?
When would you see pulsus alternans?
LV dysfunction (beat to beat variation in pulse pressure, with regular rhythm)
When would you see a dicrotic pulse?
Severe systolic dysfunction: 2 pulse peaks, one during systole, one during diastole. Best palpated in the carotid.
When would you see pulsus parvus et tardus?
Aortic stenosis: a pulse of low magnitude and delayed peak