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Flashcards in 3/31 - UW 37 Deck (50)
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31

What two reactions/enzymes reduce oxidative damage in RBCs?

G6PD and glutathione reductase

32

What drugs are purine analog antimetabolites?

6-Thiopurines
Fludarabine (CLL)
Cladribine (HCL)

33

What drugs are pyrimidine analog antimetabolites?

5-fluorouracil
Capecitabine
Cytarabine
Gemcitabine

34

How does Cladribine achieve high intracellular concentrations? What is it used for?

Resistant to adenosine deaminase. Used for Hairy Cell Leukemia.

35

Where are Major Basic Proteins found?

In eosinophil granules, help defend against parasites

36

What type of colonic polyp can transform into malignant cancer?

Adenomatous polyps, especially VILLOUS (villain!)

37

What are the most common histologic features of Glioblastoma multiforme?

Pseudopalisading necrosis
New vessel formation
Small round cells, bizarre giant cells, mitotic figures

38

Where is Glioblastoma multiforme most often found?

Butterfly distribution in the brain: Frontal and temporal lobes, crossing the midline

39

What is the cell of origin of Glioblastoma multiforme?

Astrocyte

40

Transtentorial (uncal) herniation can compress which nerve?

CN III

41

What are the 3 Ds of Botulinum?

Diplopia, Dysphagia, Dysphonia

42

What is the most common cause of recurrent lobar hemorrhages in an elderly patient?

Cerebral amyloid angiopathy

43

Where are Charcot-Bouchard aneurysms typically found? In what patients?

In the arterioles of the basal ganglia, internal capsule, and deep white matter. In patients with long-standing hypertension

44

What is responsible for the green color of pus and sputum?

Neutrophil myeloperoxidase

45

What are the cardiac anomalies seen in Turner patients?

Bicuspid aortic valve and aortic coarctation

46

When would you see pulsus paradoxus?

Cardiac tamponade

47

When would you see pulsus alternans?

LV dysfunction (beat to beat variation in pulse pressure, with regular rhythm)

48

When would you see a dicrotic pulse?

Severe systolic dysfunction: 2 pulse peaks, one during systole, one during diastole. Best palpated in the carotid.

49

When would you see pulsus parvus et tardus?

Aortic stenosis: a pulse of low magnitude and delayed peak

50

When would you see a hyperkinetic pulse?

Rapid ejection of a large SV: fever or exercise, PDA, AV fistula