Flashcards in 5/20/13 Deck (23):
Unexplained hemolytic anemia, thrombocytopenia, and acute renal failure in a normally healthy pt should raise suspicion for what?
What is the pathogenetic cause of TTP-HUS?
deficiency of or Ab against ADAMTS-13, an enzyme that cleaves vWF
What happens when there is a deficiency of ADAMTS-13?
vWF and plt clumps exhaust plt stores and cause microangiopathic hemolysis
What is the tx for TTP-HUS?
What is the most common cause of orbital cellulitis?
Bursts of atrial tachycardia followed by bradycardia on EKG is probably indicatve of what?
sick sinus syndrome (impaired AV node automaticity)
In a pt w/ CHF, at what Hb is a blood transfusion required?
In a previously healthy pt, at what hemoglobin is a blood transfusion required?
<7 or 8 g/L
Why is plt transfusion contraindicated in TTP-HUS?
it can worsen nephro and neuro Sx
Why does TTP-HUS cause confusion?
How does plasmapheresis treat TTP-HUS?
removes Abs and replenishes ADAMTS-13
What is the most specific test for acromegaly?
oral glucose tolerance test
What is the result of an oral glucose tolerance test if the pt has acromegaly?
failurew to suppress growth hormone
What is the first-line of treatment for a GH secreting macroadenoma?
What are the medical treatments for acromegaly?
somatostatin analogs (octreotide) or dopamine agonists ( cabergoline, bromocriptine)
What is the size limit for a pituitary microadenoma?
Microcytic anemia w/ normal RBC count and distribution width (RDW) strongly suggests what Dx?
How is thalassemia confirmed?
What are the results of iron studies in thalassemia?
Which type of bilirubin, conjugated or unconjugated, can be found in the urine?
Which 2 syndromes resulting from hepatic enzyme deficiencies cause conjugated hyperbilirubinemia?
Rotor's and Dubin-Johnson
How can Rotor's syndrome be differentiated from Dubin-Johnson?
Rotor's causes elevated coproporphyrin