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Flashcards in AIDS Deck (26):
1

When should prophylaxis for Pneumocystis jiroveci start?

<200 t-cells

2

What is the first-line drug for PCP prophylaxis?

TMP-SMX

3

What are the two alternative drugs for PCP prophylaxis?

Dapsone and Atavoquone

4

What are the other indications (3) for atovaquone?

malaria, toxoplasma, and babesia

5

When does prophylaxis for MAC/MAI start?

<50 T-cells

6

What is the first-line drug for MAC prophylaxis?

azithromycin

7

What is the TB treatment for an HIV pt w/ PPD induration >5mm?

INH for 9 mos

8

What vaccines should alll HIV pts get?

flu and pnuemococcal

9

What HIV med is most likely to cause anemia?

Zidovudine

10

Which anti-retroviral drugs are likely to cause hyperglycemia and hyperlipidemia?

protease inhibitors

11

Which HIV drugs are the protease inhibitors?

end in -avir (indinavir, saquinavir, nelfinavir, ritonavir)

12

What anti-retrovirals cause peripheral neuropathy and pancreatitis?

stavudine, didanosine

13

What anti-retroviral causes kidney stones?

Indinavir

14

What kind of anti-retroviral drug is indinavir?

protease inhibitor

15

What kind of anti-retroviral drug is Zidovudine (AZT)?

nucleoside analog

16

What are the requirements for a HAART regimen?

2 nucleoside RTIs + 1 protease inhibitor OR 1 non-nucleoside RTI

17

Name 3 main nucleoside reverse transcriptase inhibitors (NRTIs).

Zidovudine, Didanosine, Stavudine, Lamuvidine, abacavir

18

Name a non-nucleoside reverse-transcriptase inhibitor.

Efavirenz (or delavirdine, neviripine)

19

What is the only anti-retroviral drug contraindicated in preg?

Efavirenz

20

If pregnant woman has high T-cell count, does she need HAART?

Yes, in 2nd and 3rd trimester

21

What is post-exposure prohylaxis, say from a needle stick at the hospital or a broken condom w/ HIV+ partner?

HAART for one month

22

If you see ring-enhancing lesions in the brain on CT in an AIDS pt (CD4<100), what is the next best step?

tx w/ pyrimethamine and sulfadiazine and see if the lesions go away

23

What drug, other than ganciclovir, is for CMV?

foscarnet

24

What is the main adverse effect of ganciclovir?

myelosuppression

25

What is the main adverse effect of foscarnet?

renal toxicity

26

What is immune reconstitution inflammatory syndrome?

as T-cells go back up, some opportunistic infections come back