5/28/13 b Flashcards Preview

STEP II > 5/28/13 b > Flashcards

Flashcards in 5/28/13 b Deck (20):
1

What is the function of dystrophin, the defective protein in Duchenne muscluar dystrophy?

stabilize the plasma membrane of the myocyte

2

Proximal muscle weakness, malaise, muscle pain, fever, irritability, and violaceous rash rash on the upper eyelids in a child?

Juvenile Dermatomyositis

3

Proximal muscle weakness preceded by a prodrome of malaise, muscle pain, fever, and irritability in a child w/o the rash.

Juvenile Polymyositis

4

What disease is characterized by the onset of exercise intolerance in adolescence or early adulthood w/ fatigue, muscle cramps, myalgia, myoglobinuria, muscle swelling, and fixed weakness?

McArdle's disease (glycogen storage disease type V)

5

What is the enzyme deficiency in McArdle's disease?

muscle phosphorylase

6

What disease is characterized by weakness/degeneration of certain muscles, joint contractures, and cardiomyopathy?

Emery-Dreyfuss muscular dystrophy

7

What is the best initial test for Dx of Guillain-Barre syndrome?

CSF study

8

What tests should be used to confirm the Dx of Guillain-Barre syndrome?

electrophysiologic studies (electromyography, nerve conduction studies)

9

What psychiatric disorder is characterized by a pervasive pattern of disregard for the rights of others along with: failure to conform to social norms and laws, deceitfullness, irritability and aggressiveness, disregard for the safety of others, irresponsibility, and/or a lack of remorse after mistreating others?

Antisocial personality disorder

10

What disorder is antisocial personality disorder (necessarily) preceded by before the age of 18?

conduct disorder

11

Do erythema nodosum, hilar adenopathy, and arthritis confer a good or bad prognosis upon sarcoidosis?

g00d

12

Do lung consolidation, black race, and extrapulmonary sarcoidosis (e.g. heart block) confer a good or bad prognosis upon sarcoidosis?

bAd

13

What would cause a pt w/ an acute MI to have a murmur of mitral regurgitation?

papillary muscle dysfunction

14

How is Technetium-99m scintigraphy useful in the management of MI?

for Dx when cardiac enzymes can't be measured (e.g. when pt presents days later or if intraoperative MI)

15

Carcinomas of what 3 organs comprise most bone metastases?

breast, prostate, and lungs

16

What is given to pts in labor before administering an epidural in order to prevent aspiration pneumonitis?

antacid

17

What is the first step in mgmt of a pt in whom gonorrhea infection has been established, but there is a history of adverse reaction to penicillin?

perform penicillin skin test

18

If the penicillin allergy skin test is positive, what may be used to treat gonorrhea if the infection is minor?

macrolides (azithromycin or clarithromycin)

19

How often should pts at hi ris for colon cancer receive a colonoscopy?

every 5 years

20

Li-Fraumeni syndrome is an autosomal dominant condition caused by a germline mutation of _______; pts who have this condition are at increased risk for soft-tissue sarcomas, osteosarcomas, leukemias, brain tumors, adrenocortical malignancies, and breast cancer.

p53