Flashcards in 5/28/13 a Deck (25)
What is the tx of choice for hyperaldosteronism with bilateral adrenal hyperplasia?
spironolactone or epelerenone
What is the mech of spironolactone?
aldo receptor antagonist
What is the mechanism of action of amiloride, a K+-sparing diuretic?
blocks epithelial sodium channel (ENaC) of the distal convoluted tubule
What is the treatment of choice for pts w/ hyperaldosteronism caused by a unilateral adrenal adenoma?
What is the triad of hyperaldosteronism?
hypertension, hypokalemia, and metabolic acidosis
What are two prominent effects of trazodone that set it apart from many other antidepressants?
anxiolytic and sedative
What are the criteria for mild-pre-eclampsia?
after 20 wks, BP>140/90, proteinuria >300 mg/24hrs or >1+ on dipstick
WHat are the criteria for severe pre-eclampsia?
BP>160/110, proteinuria >5g/24hrs, or symptomatic
What is the tx for mild pre-eclampsia?
very close monitoring (prob. hospitalization) and delivery at 37 wks
Define neutropenic fever.
temp >38.0, NΦ <500
What is the first-line therapy for neutropenic fever?
What class of Abx does cefepime belong to?
4th gen cephalosporins
Cefepime's broad spectrum of activity, including what organism makes it a good choice?
What are the two forms of leprosy?
tuberculoid (paucibacillary) and lepromatous (multibacillary)
What characterizes the immune response of tuberculoid leprosy?
strong cell-mediated and weak humoral response
What characterizes the physical findings in tuberculoid leprosy?
large macular, hypopigmented or erythematous, anesthetic lesions with well-defined, raised margins
What is the result of the lepromatous skin test in tuberculoid leprosy, usually?
How is the Dx of leprosy confirmed?
What would you see on skin biopsy in a pt w/ leprosy?
inflamed nerve, acid fast bacilli, and morphologic features of the disease
What characterizes the immune response in lepromatous leprosy?
strong humoral, weak cell-mediated response
What characterizes the physical findings in lepromatous leprosy?
more disfiguring: thickened dermis, more insidious and progressive nerve disease
What is the result of the lepromatous skin test in lepromatous leprosy, usually?
Which form of leprosy carries a worse prognosis?
What is the treatment regimen for tuberculoid leprosy?
rifampin + dapsone for 6 mos