5/28/13 a Flashcards Preview

STEP II > 5/28/13 a > Flashcards

Flashcards in 5/28/13 a Deck (25):
1

What is the tx of choice for hyperaldosteronism with bilateral adrenal hyperplasia?

spironolactone or epelerenone

2

What is the mech of spironolactone?

aldo receptor antagonist

3

What is the mechanism of action of amiloride, a K+-sparing diuretic?

blocks epithelial sodium channel (ENaC) of the distal convoluted tubule

4

What is the treatment of choice for pts w/ hyperaldosteronism caused by a unilateral adrenal adenoma?

sugrical excision

5

What is the triad of hyperaldosteronism?

hypertension, hypokalemia, and metabolic acidosis

6

What are two prominent effects of trazodone that set it apart from many other antidepressants?

anxiolytic and sedative

7

What are the criteria for mild-pre-eclampsia?

after 20 wks, BP>140/90, proteinuria >300 mg/24hrs or >1+ on dipstick

8

WHat are the criteria for severe pre-eclampsia?

BP>160/110, proteinuria >5g/24hrs, or symptomatic

9

What is the tx for mild pre-eclampsia?

very close monitoring (prob. hospitalization) and delivery at 37 wks

10

Define neutropenic fever.

temp >38.0, NΦ <500

11

What is the first-line therapy for neutropenic fever?

cefepime

12

What class of Abx does cefepime belong to?

4th gen cephalosporins

13

Cefepime's broad spectrum of activity, including what organism makes it a good choice?

Pseudomonas

14

What are the two forms of leprosy?

tuberculoid (paucibacillary) and lepromatous (multibacillary)

15

What characterizes the immune response of tuberculoid leprosy?

strong cell-mediated and weak humoral response

16

What characterizes the physical findings in tuberculoid leprosy?

large macular, hypopigmented or erythematous, anesthetic lesions with well-defined, raised margins

17

What is the result of the lepromatous skin test in tuberculoid leprosy, usually?

(+)

18

How is the Dx of leprosy confirmed?

skin biopsy

19

What would you see on skin biopsy in a pt w/ leprosy?

inflamed nerve, acid fast bacilli, and morphologic features of the disease

20

What characterizes the immune response in lepromatous leprosy?

strong humoral, weak cell-mediated response

21

What characterizes the physical findings in lepromatous leprosy?

more disfiguring: thickened dermis, more insidious and progressive nerve disease

22

What is the result of the lepromatous skin test in lepromatous leprosy, usually?

(-)

23

Which form of leprosy carries a worse prognosis?

lepromatous

24

What is the treatment regimen for tuberculoid leprosy?

rifampin + dapsone for 6 mos

25

What is the treatment regimen for lepromatous leprosy?

rifampin + dapsone + clofazimine for 12 mos