HY Pharm 1 Flashcards Preview

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Flashcards in HY Pharm 1 Deck (25)
2

Inhibitors of CYP450

*Cimetidine, ketoconazole, erythromycin, isoniazid and grapefruit

3

Ability of drug to produce a biologic effect

*Efficacy

4

Mechanism of action (MOA) utilizes intracellular receptors

*Thyroid and steroid hormones

5

MOA utilizes transmembrane receptors

*Insulin

6

Antidote used for organophosphate/anticholinesterase poisoning

**Atropine, pralidoxime (2-PAM)

7

Antidote used for acetaminophen (APAP) toxicity

*N-acetylcysteine

8

Antidote used for heparin toxicity

**Protamine Sulfate

9

Antidote used for warfarin toxicity

*Vitamin K and Fresh frozen plasma (FFP)

10

Antidote for tissue plasminogen activator (t-PA), streptokinase

**Aminocaproic acid

11

Antidote used for opioid toxicity

*Naloxone (IV), naltrexone (PO)

12

Antidote used for benzodiazepine toxicity

*Flumazenil

13

Interaction with this drug requires dose reduction of 6-MP

**Allopurinol

14

May protect against doxorubicin cardio-toxicity by chelating iron

*Dexrazoxane

15

Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis

*Bleomycin

16

Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest

**Paclitaxel (taxol)

17

Anti-estrogen used for estrogen receptor + breast cancer

**Tamoxifen

18

Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist

*Odansetron, granisetron, dolasetron, palonosetron

19

Hormone inhibiting prolactin release

*Dopamine

20

ACTH analog used for diagnosis of patients with corticosteroid abnormality

**Cosyntropin

21

Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis

*Desmopressin (DDAVP)

22

Most widely used thyroid drugs such as Synthroid and Levoxyl contain

**L-thyroxine (T4)

23

Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy

*PTU

24

PTU (propylthiouracil) MOA

*Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin

25

Some side effects of corticosteroids

*Hyperglycemia, Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis

26

Diuretic used to antagonize aldosterone receptors

*Spironolactone