HY Pharm 1

Question 2

Inhibitors of CYP450

Answer 2

*Cimetidine, ketoconazole, erythromycin, isoniazid and grapefruit

Question 3

Ability of drug to produce a biologic effect

Answer 3

*Efficacy

Question 4

Mechanism of action (MOA) utilizes intracellular receptors

Answer 4

*Thyroid and steroid hormones

Question 5

MOA utilizes transmembrane receptors

Answer 5

*Insulin

Question 6

Antidote used for organophosphate/anticholinesterase poisoning

Answer 6

**Atropine, pralidoxime (2-PAM)

Question 7

Antidote used for acetaminophen (APAP) toxicity

Answer 7

*N-acetylcysteine

Question 8

Antidote used for heparin toxicity

Answer 8

**Protamine Sulfate

Question 9

Antidote used for warfarin toxicity

Answer 9

*Vitamin K and Fresh frozen plasma (FFP)

Question 10

Antidote for tissue plasminogen activator (t-PA), streptokinase

Answer 10

**Aminocaproic acid

Question 11

Antidote used for opioid toxicity

Answer 11

*Naloxone (IV), naltrexone (PO)

Question 12

Antidote used for benzodiazepine toxicity

Answer 12

*Flumazenil

Question 13

Interaction with this drug requires dose reduction of 6-MP

Answer 13

**Allopurinol

Question 14

May protect against doxorubicin cardio-toxicity by chelating iron

Answer 14

*Dexrazoxane

Question 15

Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis

Answer 15

*Bleomycin

Question 16

Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest

Answer 16

**Paclitaxel (taxol)

Question 17

Anti-estrogen used for estrogen receptor + breast cancer

Answer 17

**Tamoxifen

Question 18

Anti-emetics used in association with anti-cancer drugs that are 5-HT3 (serotonin receptor subtype ) antagonist

Answer 18

*Odansetron, granisetron, dolasetron, palonosetron

Question 19

Hormone inhibiting prolactin release

Answer 19

*Dopamine

Question 20

ACTH analog used for diagnosis of patients with corticosteroid abnormality

Answer 20

**Cosyntropin

Question 21

Synthetic analog of ADH hormone used for diabetes insipidus and nocturnal enuresis

Answer 21

*Desmopressin (DDAVP)

Question 22

Most widely used thyroid drugs such as Synthroid and Levoxyl contain

Answer 22

**L-thyroxine (T4)

Question 23

Thioamide less likely to cross placenta, inhibits peripheral conversion of T4 to T3 in high doses, and should be used with extreme caution in pregnancy

Answer 23

*PTU

Question 24

PTU (propylthiouracil) MOA

Answer 24

*Inhibits thyroid hormone synthesis by blocking iodination of the tyrosine residues of thyroglobulin

Question 25

Some side effects of corticosteroids

Answer 25

*Hyperglycemia, Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis

Question 26

Diuretic used to antagonize aldosterone receptors

Answer 26

*Spironolactone