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Flashcards in Pharm 14 Deck (30)
2

Treatment of withdrawal syndrome involves

Long-acting sedative-hypnotic or a gradual reduction of dose, clonidine or propranolol

3

Withdrawal from this drug causes lethargy, irritability, and headache

Caffeine

4

W/D from this drug causes anxiety and mental discomfort

Nicotine

5

Chronic high dose abuse of nicotine leads to

Psychotic state, overdose causes agitation, restlessness, tachycardia, hyperthermia, hyperreflexia, and seizures

6

Tolerance is marked and abstinence syndrome occurs

Amphetamines

7

Amphetamine agents

Dextroamphetamines and methamphetamine

8

These agents are congeners of Amphetamine

DOM, STP, MDA, and MDMA "ecstasy"

9

Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias, seizures, respiratory depression, or severe HTN (MI and stroke)

Cocaine "super-speed"

10

Most dangerous of the currently popular hallucinogenic drugs, OD leads to nystagmus, marked hypertension, and seizures, presence of both horizontal and vertical nystagmus is pathognomonic

PCP

11

Removal of PCP may be aided

Urinary acidification and activated charcoal or continual nasogastric suction

12

Only direct acting agent that is very lipid soluble and used in glaucoma

Pilocarpine

13

These agents are used to treat dry mouth in Sj_gren's syndrome

Pilocarpine or Cevimeline

14

Indirect-Acting ACh Agonist, alcohol, short DOA and used in diagnosis of myasthenia gravis

Edrophonium

15

Carbamate with intermediate action postoperative and neurogenic ileus and urinary retention

Neostigmine

16

Treatment of atropine overdose and glaucoma (because lipid soluable). Enters the CNS rapidly and has a stimulant effect, which may lead to convulsions

Physostigmine

17

Treatment of myasthenia gravis

Pyridostigmine

18

Antiglaucoma organophosphate

Echothiophate

19

Associated with an increased incidence of cataracts in patients treated for glaucoma

Long acting cholinesterase inhibitors

20

Scabicide organophosphate

Malathion

21

The most important cause of acute deaths in cholinesterase inhibitor toxicity

Respiratory failure

22

The most toxic organophosphate

Parathion

23

Treatment of muscarinic symptoms in organophosphate overdose

Atropine

24

This agent regenerates active cholinesterase and is a chemical antagonist used to treat organophosphate exposure

Pralidoxime

25

Prototypical drug is atropine

Nonselective Muscarinic Antagonists

26

Cystitis, postoperative bladder spasms, or incontinence

Oxybutynin, dicyclomine

27

Toxicity of anticholinergics

Anti-DUMBBELSS

28

Another pneumonic for anticholinergic toxicity

"dry as a bone, red as a beet, mad as a hatter, hot as a hare, blind as a bat"

29

Atropine fever is the most dangerous effect and can be lethal in this population group

Infants

30

Contraindications to use of atropine

Infants, closed angle glaucoma, prostatic hypertrophy

31

Prototype ganglion blocker

Hexamethonium