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Flashcards in Pharm 19 Deck (32)
2

SE of HMG COA reductase inhibitors

Rhabdomyolysis and Hepatotoxicity

3

Cutaneous flush due to niacin can be reduced by pretreatment with

Aspirin

4

Most common SE of fibrates

Nausea

5

Fibrates are contraindicated in

Pregnancy

6

Concurrent use of fibrates and statins increases risk of

Rhabdomyolysis

7

Class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins

Ezetimibe (Zetia)

8

MOA of NSAIDS

inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)

9

Difference between aspirin and other NSAIDS

Aspirin irreversibly inhibits cyclooxygenase

10

Four main actions of NSAIDS

Anti-inflammatory, analgesia, antipyretic and antiplatelet activity

11

Aspirin is contraindicated in children with viral infection

Potential for development of Reye's syndrome

12

SE of salicylates

Tinnitus, GI bleeding

13

NSAID also available as an ophthalmic preparation

Diclofenac

14

NSAID available orally, IM and ophthalmically

Ketoralac

15

NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity

Ketoralac

16

Newer NSAIDs that selectively inhibit COX-2

Celecoxib and rofecoxib

17

COX 2 inhibitors may have reduced risk of

Gastric ulcers and GI Bleeding

18

COX 2 inhibitors should be used cautiously in pts with

Pre-existing cardiac or renal disease

19

SE of acetaminophen

Hepatotoxicity

20

MOA of gold salts

Alter activity of macrophages and suppress phagocytic activity of PMNs

21

SE of gold salts

Dermatitis of the mouth aplastic anemia and agranulocytosis

22

Causes bone marrow suppression

Methotrexate

23

SE of penicillamine

Aplastic anemia and renal

24

Interferes with activity of T-lymphocytes

Hydroxychloroquine

25

Anti-malarial drug used in rheumatoid arthritis (RA)

Hydroxychloroquine

26

SE of hydroxychloroquine

Retinal destruction and dermatitis

27

MOA of Leflunomide (newer agent)

Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis

28

Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)

Infliximab and etanercept

29

Anti-rheumatic agent also used for ulcerative colitis

Sulfasalazine

30

NSAID contraindicated in gout

Aspirin

31

MOA of Colchicine (used in acute gout)

Selective inhibitor of microtubule assembly

32

SE of colchicine

Kidney and liver toxicity

33

Agent used to treat chronic gout by increasing uric acid excretion

Probenecid causes urinary excretion of uric acid and lowers serum urate concentrations