Pharm 9

Question 2

Benzodiazepine with useful relaxant effects in skeletal muscle spasticity of central origin

Answer 2

Diazepam

Question 3

Benzodiazepine that has efficacy against absence seizures and in anxiety states, such as agoraphobia

Answer 3

Clonazepam

Question 4

Benzodiazepines that are the most effective in the treatment of panic disorder

Answer 4

Alprazolam and Clonazepam

Question 5

Benzodiazepine that is used for anesthesia

Answer 5

Midazolam

Question 6

DOC for status epilepticus

Answer 6

Diazepam

Question 7

Longer acting benzodiazepines used in the management of withdrawal states of alcohol and other drugs

Answer 7

Chlordiazepoxide and Diazepam

Question 8

Benzos having active metabolites, long half lives, and a high incidence of adverse effects

Answer 8

Diazepam, Flurazepam, chlordiazepoxide, and clorazepate

Question 9

Barbiturates may precipitate this hematologic condition

Answer 9

Acute intermittent porphyria

Question 10

Barbiturates decrease the effectiveness of many other drugs via this pharmacokinetics property

Answer 10

Liver enzyme INDUCTION

Question 11

Barbiturates MOA

Answer 11

Increase the DURATION of GABA-mediated chloride ion channels

Question 12

Barbiturate used for the induction of anesthesia

Answer 12

Thiopental

Question 13

Important drug interaction with chloral hydrate

Answer 13

May displace coumadin from plasma proteins

Question 14

Site of action for zaleplon and zolpidem

Answer 14

Benzodiazepine receptor BZ1 (although are not considered benzodiazepines)

Question 15

Good hypnotic activity with less CNS SE than most benzodiazepines

Answer 15

Zolpidem, zaleplon

Question 16

Agent that is a partial agonist for the 5-HT1A receptor

Answer 16

Buspirone

Question 17

DOC for generalized anxiety disorder, NOT effective in acute anxiety

Answer 17

Buspirone

Question 18

Rate limiting step of alcohol metabolism

Answer 18

Aldehyde dehydrogenase

Question 19

Agent that metabolizes acetaldehyde to acetate

Answer 19

Aldehyde dehydrogenase

Question 20

Agents that inhibit aldehyde dehydrogenase

Answer 20

Disulfiram, metronidazole, certain sulfonylureas and cephalosporins

Question 21

Agent used in the treatment of alcoholism, if alcohol is consumed concurrently, acetaldehyde builds up and results in nausea, headache, flushing, and hypotension

Answer 21

Disulfiram

Question 22

Agent that competes for alcohol dehydrogenase in the case of methanol overdose

Answer 22

Ethanol

Question 23

Drug that inhibits alcohol dehydrogenase and is used in ethylene glycol exposure

Answer 23

Fomepizole

Question 24

MOA for Phenytoin, Carbamazepine, Lamotrigine

Answer 24

Sodium blockade

Question 25

MOA for benzodiazepines and barbiturates

Answer 25

GABA Cl- channels

Benzos - inc FREQUENCY
Barbs - inc duration

Question 26

MOA for Ethosuximide

Answer 26

Blocks Calcium channels DOC - Absence seizures

Question 27

MOA for Valproic acid at high doses

Answer 27

Affect calcium, potassium, and sodium channels

Question 28

DOC for febrile seizures

Answer 28

Phenobarbital

Question 29

Inhalant anesthetics

Answer 29

NO, chloroform, and diethyl ether

Question 30

Toxic to the liver, kidney, lungs, bone marrow, peripheral nerves, and cause brain damage in animals, sudden death has occurred following inhalation

Answer 30

Fluorocarbons and Industrial solvents

Question 31

Inhalant that causes dizziness, tachycardia, hypotension, and flushing

Answer 31

Organic nitrites

Question 32

Causes acne, premature closure of epiphyses, masculinization in females, hepatic dysfunction, MI, and increases in libido and aggression

Answer 32

Steroids