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Flashcards in HY Pharm 2 Deck (25)
2

Common SE of spironolactone

**Gynecomastia and hyperkalemia

3

Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and currently being tested for treatment of breast cancer (Stars study)

*Raloxifene

4

Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy

*Diethylstilbestrol (DES)

5

Converted to more active form DHT by 5 alpha-reductase

*Testosterone

6

Product of proinsulin cleavage used to assess insulin production

*C-peptide

7

Long acting insulin

*Ultralente (humulin U)

8

Amino acid derivative for treatment of Type II diabetes

*Nateglinide

9

Increase bone density, also being tested for breast CA tx.

*Raloxifene (SERM-selective estrogen receptor modulator)

10

Used intranasally and decreases bone resorption

*Calcitonin (salmon prep)

11

Drug that causes contraction of the uterus

*Oxytocin

12

Distribution of histamine receptors H1, H2, and H3

*Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively

13

Prototype antagonist of H1 and H2 receptors

*Diphenhydramine

14

1st generation antihistamine that is highly sedating

**Diphendydramine

15

2nd generation antihistamines

*Fexofenadine, loratadine, and cetirizine

16

H2 blocker that causes the most interactions with other drugs

*Cimetidine

17

5HT-1D/1B agonist used for migraine headaches

**Sumatriptan, naratriptan, and rizatriptan

18

Agents for reduction of postpartum bleeding

**Oxytocin and ergonovine

19

Agents used in treatment of carcinoid tumor

**Cyproheptadine

20

5HT-3 antagonist used in chemotherapeutic induced emesis

Aprepitant, Ondansetron, granisetron, dolasetron and palonosetron

21

Ergot alkaloid used as an illicit drug

*LSD

22

Dopamine agonist used in hyperprolactinemia

*Bromocriptine

23

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

*Bradykinin

24

Drug causing depletion of substance P (vasodilator)

*Capsaicin

25

Prostaglandins that cause abortions

*Prostaglandin E1 (misoprostol) PGE2, and PGF2alpha

26

Inhibitor of lipoxygenase

*Zileuton