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Flashcards in Pharm 4 Deck (30)
2

GnRH agonist used for infertility - pulsatile usage
Different types of CA - steady usage

Leuprolide

3

GnRH antagonist with more immediate effects, used for infertility

Ganirelix

4

T3 compound less widely used

Cytomel

5

Anti-thyroid drugs

Thioamides, iodides, radioactive iodine, and ipodate

6

Thioamide agents used in hyperthyroidism

Methimazole and propylthiouracil (PTU)

7

Can be effective for short term therapy of thyroid storm, but after several weeks of therapy causes an exacerbation of hyperthyroidism

Iodide salts

8

Permanently cures thyrotoxicosis, patients will need thyroid replacement therapy thereafter. Contraindicated in pregnancy

Radioactive iodine

9

Radio contrast media that inhibits the conversion of T4 to T3

Ipodate

10

Block cardiac adverse effects of thyrotoxicosis such as tachycardia, inhibits the conversion of T4 to T3

Beta-blockers such as propranolol

11

3 zones of adrenal cortex and their products

"GFR"
Glomerulosa (mineralocorticoids)
Fasciculata (glucocorticoid=GC)
Reticularis (adrenal androgens)

12

Pneumonic for 3 zones of adrenal cortex

GFR

13

Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)

Glucocorticoids

14

Short acting GC's

Cortisone and hydrocortisone (equivalent to cortisol)

15

Intermediate acting GC's

Prednisone, methylprednisolone, prednisolone, and triamcinolone

16

Long acting GC's

Betamethasone, dexamethasone, and paramethasone

17

Mineralocorticoids

Fludrocortisone and deoxycorticosterone

18

Period of time of therapy after which GC therapy will need to be tapered

5-7 days

19

Used for Cushing's syndrome (increased corticosteroid) and sometimes for adrenal function test

Metyrapone

20

Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis

Aminoglutethimide

21

Antifungal agent used for inhibition of all gonadal and adrenal steroids

Ketoconazole

22

Antiprogestin used as potent antagonist of GC receptor

Mifepristone

23

Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss

Estrogen

24

Antiestrogen drugs used for fertility and breast cancer respectively

Clomiphene and tamoxifen

25

Common SE of tamoxifen and raloxifene

Hot flashes

26

Estrogen mostly used in oral contraceptives (OC)

Ethinyl estradiol and mestranol

27

Anti-progesterone used as abortifacient

Mifepristone (RU-486)

28

Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)

Combination oral contraceptives (OC)

29

Oral contraceptive available in a transdermal patch

Ortho-Evra

30

5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness

Finasteride (Proscar and Propecia respectively)

31

Anabolic steroid that has potential for abuse

Nandrolone and stanozolol