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Flashcards in Immuno/Micro Deck (43)
1

Anti-nuclear Abs

SLE, nonspecific

2

Anti-dsDNA

SLE

3

Anti-Smith

SLE

4

Antihistone

Drug-induced lupus

5

Anti-IgG (Rheumatoid factor)

RA

6

Anticentrosome

Scleroderma (CREST)

7

Anti-Scl70 (anti-DNA topoisomerase I)

Scleroderma (diffuse)

8

Anti-mitochondrial

Primary biliary cirrhosis

9

Antigliadin

Celiac

10

Antiendomysial

Celiac

11

Anti-basement membrane

Goodpasture's

12

Anti-desmoglein

Pemphigus vulgaris

13

Antimicrosomal

Hashimoto's

14

Antithyroglobulin

Hashimoto's

15

Anti-Jo-1

Polymyostitis, dermatomyostitis

16

Anti-SS-A (anti-Ro)

Sjogren's

17

Anti-SS-B (Anti-La)

Sjogrens's

18

Anti-U1 RNP

Mixed CT disease

19

Anti-smooth muscle

Autoimmune hepatitis

20

Anti-glutamate decarboxylase

Type 1 DM

21

c-ANCA

Wegener's

22

p-ANCA

Churg-Strauss (asthma)
Polyangitis
Ulcerative colitis

23

Recurrent infections with Staph, Kleb, serratia, cacdida, PA and aspergillus.

CGD

NADPH oxidase deficiency
Catalase + bacteria infections
NBT test yellow (-)

24

IgA in small vessel walls

Henoch-Schonlein purpura

25

Recurrent infections, omphalitis, gum inflammation, CD18-

Leukocyte adhesion deficiency

No integrins = no leukocyte migration
Failure to form pus

26

Partial albinism, recurrent bacterial infections, CD56-

Chediak-Higashi

27

Recurrent infections with Candida, no anti-CD3, no concanavalin or phytohemagglutinin

DiGeorge syndrome

No T-cells
Failure of 3rd and 4th pouches
Facial abnormalities, cardiac
No live vaccines

28

MHC class I deficiency

Failure of TAP1
NO CD8
CD4 normal
Normal DTH, Ab

29

MHC class II deficiency

SCID
No CD4

30

Recurrent meningitis or gonoccoal infections

C5-9 (MAC) deficiency
Tx = ceftriaxone

31

C1-inhibitor deficiency

Hereditary angioedema

32

C1-4

Viral Neutralization

33

C3b

Opsonization (also IgG)

34

C3a, C5a

Anaphylatoxins
Binds mast cells directly

35

C5a

Neutrophil Chemotaxis

36

C5b-9

MAC

37

Pneumonia for 6mo. Recurrent infections w/ encapsulated bacteria and viral infections, CD19-

Bruton's
Tyrosine Kinase

No B-cells
CD19-

38

Recurrent bacterial infections and severe diarrhea, high serum IgM

Hyper IgM
Deficiency of CD40L

39

Most common immune deficiency

IgA deficiency
Repeated sinopulmonary & GI infections

40

Deficiency of gamma chain IL-2

X-linked SCID

41

Adenosine deaminase deficiency

SCID

42

Recombinase deficiency

SCID
Rag1 or 2 nonsense mutations
No B or T cells

43

Thrombocytopenic purpura, eczema, low Ig

Wiskott-Aldrich syndrome

Classic triad