Immuno/Micro

Question 1

Anti-nuclear Abs

Answer 1

SLE, nonspecific

Question 2

Anti-dsDNA

Answer 2

SLE

Question 3

Anti-Smith

Answer 3

SLE

Question 4

Antihistone

Answer 4

Drug-induced lupus

Question 5

Anti-IgG (Rheumatoid factor)

Answer 5

RA

Question 6

Anticentrosome

Answer 6

Scleroderma (CREST)

Question 7

Anti-Scl70 (anti-DNA topoisomerase I)

Answer 7

Scleroderma (diffuse)

Question 8

Anti-mitochondrial

Answer 8

Primary biliary cirrhosis

Question 9

Antigliadin

Answer 9

Celiac

Question 10

Antiendomysial

Answer 10

Celiac

Question 11

Anti-basement membrane

Answer 11

Goodpasture’s

Question 12

Anti-desmoglein

Answer 12

Pemphigus vulgaris

Question 13

Antimicrosomal

Answer 13

Hashimoto’s

Question 14

Antithyroglobulin

Answer 14

Hashimoto’s

Question 15

Anti-Jo-1

Answer 15

Polymyostitis, dermatomyostitis

Question 16

Anti-SS-A (anti-Ro)

Answer 16

Sjogren’s

Question 17

Anti-SS-B (Anti-La)

Answer 17

Sjogrens’s

Question 18

Anti-U1 RNP

Answer 18

Mixed CT disease

Question 19

Anti-smooth muscle

Answer 19

Autoimmune hepatitis

Question 20

Anti-glutamate decarboxylase

Answer 20

Type 1 DM

Question 21

c-ANCA

Answer 21

Wegener’s

Question 22

p-ANCA

Answer 22

Churg-Strauss (asthma)
Polyangitis
Ulcerative colitis

Question 23

Recurrent infections with Staph, Kleb, serratia, cacdida, PA and aspergillus.

Answer 23

CGD

NADPH oxidase deficiency
Catalase + bacteria infections
NBT test yellow (-)

Question 24

IgA in small vessel walls

Answer 24

Henoch-Schonlein purpura

Question 25

Recurrent infections, omphalitis, gum inflammation, CD18-

Answer 25

Leukocyte adhesion deficiency No integrins = no leukocyte migration Failure to form pus

Question 26

Partial albinism, recurrent bacterial infections, CD56-

Answer 26

Chediak-Higashi

Question 27

Recurrent infections with Candida, no anti-CD3, no concanavalin or phytohemagglutinin

Answer 27

DiGeorge syndrome No T-cells Failure of 3rd and 4th pouches Facial abnormalities, cardiac No live vaccines

Question 28

MHC class I deficiency

Answer 28

Failure of TAP1 NO CD8 CD4 normal Normal DTH, Ab

Question 29

MHC class II deficiency

Answer 29

SCID | No CD4

Question 30

Recurrent meningitis or gonoccoal infections

Answer 30

C5-9 (MAC) deficiency | Tx = ceftriaxone

Question 31

C1-inhibitor deficiency

Answer 31

Hereditary angioedema

Question 32

C1-4

Answer 32

Viral Neutralization

Question 33

C3b

Answer 33

Opsonization (also IgG)

Question 34

C3a, C5a

Answer 34

Anaphylatoxins | Binds mast cells directly

Question 35

C5a

Answer 35

Neutrophil Chemotaxis

Question 36

C5b-9

Answer 36

MAC

Question 37

Pneumonia for 6mo. Recurrent infections w/ encapsulated bacteria and viral infections, CD19-

Answer 37

Bruton's Tyrosine Kinase No B-cells CD19-

Question 38

Recurrent bacterial infections and severe diarrhea, high serum IgM

Answer 38

Hyper IgM | Deficiency of CD40L

Question 39

Most common immune deficiency

Answer 39

IgA deficiency | Repeated sinopulmonary & GI infections

Question 40

Deficiency of gamma chain IL-2

Answer 40

X-linked SCID

Question 41

Adenosine deaminase deficiency

Answer 41

SCID

Question 42

Recombinase deficiency

Answer 42

SCID Rag1 or 2 nonsense mutations No B or T cells

Question 43

Thrombocytopenic purpura, eczema, low Ig

Answer 43

Wiskott-Aldrich syndrome Classic triad