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Flashcards in Pharm 10 Deck (34)
2

DOCs for status epilepticus

IV diazepam (or lorazapam) followed by phenytoin

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Drugs that can be used for infantile spasms

Corticosteroids

4

Anti-seizure drugs used also for bipolar affective disorder (BAD)

Valproic acid, carbamazepine, phenytoin and gabapentin

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Anti-seizure drugs used also for Trigeminal neuralgia

Carbamazepine

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Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism

Phenytoin

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Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida

Carbamazepine

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Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress

Valproic acid

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Laboratory value required to be monitored for patients on valproic acid

Serum ammonia and LFT's

10

SE for Lamotrigine

Stevens-Johnson syndrome

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SE for Felbamate

Aplastic anemia and acute hepatic failure

12

Anti-seizure medication also used in the prevention of migraines

Valproic acid

13

Carbamazepine may cause

Agranulocytosis

14

Anti-seizure drugs used as alternative drugs for mood stabilization

Carbamazepine, gabapentin, lamotrigine, and valproic acid

15

MOA of general anesthetics

Unclear, thought to increase the threshold for firing of CNS neurons

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Inhaled anesthetic with a low blood/gas partition coefficient

Nitrous oxide

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Inversely related to potency of anesthetics

Minimum alveolar anesthetic concentration (MAC)

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Inhaled anesthetics metabolized by liver enzymes which has a major role in the toxicity of these agents

Halothane and methoxyflurane

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Most inhaled anesthetics SE

Decrease arterial blood pressure

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Inhaled anesthetics are myocardial depressants

Enflurane and halothane

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Inhaled anesthetic causes peripheral vasodilation

Isoflurane

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Inhaled anesthetic that may sensitize the myocardium to arrhythmogenic effects of catecholamines and has produced hepatitis

Halothane

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Inhaled anesthetics, less likely to lower blood pressure than other agents, and has the smallest effect on respiration

Nitrous oxide

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Fluoride released by metabolism of this inhaled anesthetic may cause renal insufficiency

Methoxyflurane

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Prolonged exposure to this inhaled anesthetic may lead to megaloblastic anemia

Nitrous oxide

26

Pungent inhaled anesthetic which leads to high incidence of coughing and vasospasm

Desflurane

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IV barbiturate used as a pre-op anesthetic

Thiopental

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Benzodiazepine used adjunctively in anesthesia

Midazolam

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This produces "dissociative anesthesia", is a cardiovascular stimulant which may increases intracranial pressure, and hallucinations occur during recovery

Ketamine

30

State of analgesia and amnesia produced when fentanyl is used with droperidol and nitrous oxide

Neuroleptanesthesia

31

Produces both rapid anesthesia and recovery, has antiemetic activity and commonly used for outpatient surgery, may cause marked hypotension

Propofol

32

Most commonly abused in health care professionals

Heroin, morphine, oxycodone, meperidine and fentanyl

33

This route is associated with rapid tolerance and psychologic dependence

IV administration

34

Lacrimation, rhinorrhea, yawning, sweating, weakness, gooseflesh, nausea, and vomiting, tremor, muscle jerks, and hyperpnea are signs of this syndrome

Abstinence syndrome

35

Treatment for opioid addiction

Methadone, followed by slow dose reduction