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Flashcards in Pharm 3 Deck (25)
2

MOA of cisplatin

Alkylating agent

3

Common toxicities of cisplatin

Nephro and ototoxicity

4

Analog of hypoxanthine, needs HGPRTase for activation

6-mercaptopurine (6-MP)

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Bleomycin + vinblastine + etoposide + cisplatin produce almost a 100% response when all agents are used for this neoplasm

Testicular cancer

6

MOPP regimen used in Hodgkin's disease (HD)

Mechlorethamine + oncovorin (vincristine) + procarbazine, and prednisone

7

ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP

Adriamycin (doxorubicin) + bleomycin, vinblastine + dacarbazine

8

Regimen used for non-Hodgkin's lymphoma

COP (cyclophosphamide, oncovorin (vincristine), and prednisone)

9

Regimen used for breast cancer

CMF (cyclophosphamide, methotrexate, and fluorouracil) and tamoxifen if Estrogen-Receptor +

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Alkylating agent, vesicant that causes tissue damage with extravasation

Mechlorethamine

11

Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis

Cyclophosphamide

12

Prevention of cyclophosphamide induced hemorrhagic cystitis

Hydration and mercaptoethanesulfonate (MESNA)

13

Microtubule inhibitor that causes peripheral neuropathy, foot drop (eg. ataxia), and "pins and needles" sensation

Vincristine

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Toxicities include nephrotoxicity and ototoxicity, leading to a severe interaction with aminoglycosides

Cisplatin

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Agent similar to cisplatin, less nephrotoxic, but greater myelosuppression

Carboplatin

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Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine)

L-asparaginase

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Used for hairy cell leukemia; it stimulates NK cells

Interferon alpha

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Anti-androgen used for prostate cancer

Flutamide (Eulexin)

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Newer estrogen receptor antagonist used in advanced breast cancer

Toremifene (Fareston)

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Some cell cycle specific anti-cancer drugs

Bleomycin, antimetabolites (5-FU, 6-MP, MTX, etoposide), vinca alkaloids

"BAV"

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Some cell cycle non-specific drugs

Alkylating agents (mechlorethamine, cyclophosphamide), nitrosourea, cisplatin, antibiotics (doxorubicin, daunorubicin)

ANCA

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Nitrosoureas with high lipophilicity, used for brain tumors

Carmustine (BCNU) and lomustine (CCNU)

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Alkylating agent that produces disulfiram-like reaction with ethanol

Procarbazine

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Somatostatin (SRIF) analog used for acromegaly, carcinoid, glucagonoma and other GH producing pituitary tumors

Octreotide

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Somatotropin (GH) analog used in GH deficiency (dwarfism)

Somatrem

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GHRH analog used as diagnostic agent

Sermorelin