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Flashcards in Pharm 6 Deck (30)
2

MOA of thiazolindinediones

Stimulate PPAR-gamma receptor to regulate CHO and lipid metabolism

3

SE of Thiazolindinediones

Weight gain, edema, hepatotoxicity (3A4), worsens CHF --> HF, fracture, bladder cancer

4

Hyperglycemic agent that increases cAMP and results in glycogenolysis, gluconeogenesis, reverses hypoglycemia, also used to reverse severe beta-blocker overdose and smooth muscle relaxation

Glucagon

5

Available bisphosphonates

Alendronate, etidronate, risedronate, pamidronate, tiludronate, and zoledronic acid

6

MOA of Bisphosphonates

Inhibits osteoclast bone resorption

7

Uses of bisphosphonates

Osteoporosis, Paget's disease, and osteolytic bone lesions, and hypercalcemia from malignancy

8

Major SE of bisphosphonates

Chemical esophagitis

9

Bisphosphonates that cannot be used on continuous basis because it caused osteomalacia

Etidronate

10

Used for prevention of postmenopausal osteoporosis in women

Calcium reguators Bisphosphonates: alendronate, risedronate, ibandronate, Estrogen (HRT-Hormone replacement therapy)

11

Used especially in postmenopausal women, dosage should be 1500 mg

Calcium

12

Vitamin given with calcium to ensure proper absorption

Vitamin D

13

Disease caused by excess ergot alkaloids

St. Anthony's Fire

14

Endogenous substances commonly interpreted as histamine, serotonin, prostaglandins, and vasoactive peptides

Autocoids

15

Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea

Zollinger-Ellison Syndrome

16

Generation of antihistamine that has the most CNS effects

First generation due to being more lipid-soluble

17

Major indication for H1 receptor antagonist

Use in IgE mediated allergic reaction

18

Antihistamine that can be used for anxiety and insomnia and is not addictive

hydroxyzine (Atarax)

19

H1 antagonist used in motion sickness

Dimenhydrinate, meclizine, and other 1st generation

20

Most common side effect of 1st generation antihistamines

Sedation

21

Lethal arrhythmias resulting from concurrent therapy with azole fungals (metabolized by CYP 3A4) and these antihistamines which inhibit the 3A4 iso-enzyme.

Terfenadine and astemizole (have been removed from the market)

22

Clinical use for H2 blockers

Acid reflux disease, duodenal ulcer and peptic ulcer disease

23

Receptors for serotonin (5HT-1) are located

Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

24

Triptan available in parenteral and nasal formulation

Sumatriptan

25

H1 blocker that is also a serotonin antagonist

Cyproheptadine

26

5HT2 antagonist mediate synaptic excitation in the CNS and smooth muscle contraction

Ketanserin, cyproheptadine, and ergot alkaloids (partial agonist of alpha and serotonin receptors)

27

5ht-3 antagonist that has been MOST associated with QRS and QTc prolongation and should not be used in patients with heart disease

Dolasetron

28

Drug used in ergot alkaloids overdose, ischemia and gangrene

Nitroprusside

29

Reason ergot alkaloids are contraindicated in pregnancy

Uterine contractions

30

SE of ergot alkaloids

Hallucinations resembling psychosis

31

Peptide causing increased capillary permeability and edema

Bradykinin and histamine