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Flashcards in Pharm 1 Deck (24)
2

Relates the amount of drug in the body to the plasma concentration

Volume of distribution (VD)

3

Plasma concentration of a drug at a given time

Cp

4

The ratio of the rate of elimination of a drug to its plasma concentration

Clearance (CL)

5

The elimination of drug that occurs before it reaches the systemic circulation

First pass effect

6

The fraction of administered dose of a drug that reaches systemic circulation

Bioavailability (F)

7

When the rate of drug input equals the rate of drug elimination

Steady state

8

Different steps of Phase I

Hydrolysis, oxidation, reduction

(That 1 is a HOR)

9

Products of Phase II conjugation

Glucuronate, acetic acid, and glutathione sulfate

(GAS - glucuronidation, acetylation, sulfation)

10

Constant percentage of substrate metabolized per unit time

First order kinetics

11

Drug elimination with a constant amount metabolized regardless of drug concentration

Zero order kinetics

12

Target plasma concentration x (volume of distribution / bioavailability)

Loading dose (Cp*(Vd/F))

13

Concentration in the plasma x (clearance / bioavailability)

Maintenance dose (Cp*(CL/F))

14

Strength of interaction between drug and its receptor

Affinity

15

Selectivity of a drug for its receptor

Specificity

16

Amount of drug necessary to elicit a biologic effect

Potency

17

Ability of a drug to produce 100% of the maximum response regardless of the potency

Full agonist

18

Ability to produce less than 100% of the response

Partial agonist

19

Ability to bind reversibly to the same site as the drug and without activating the effector system

Competitive antagonist

20

Ability to bind to either the same or different site as the drug

Noncompetitive antagonist

21

MOA utilizes ligand gated ion channels

Benzodiazepines and calcium channel blockers

22

Median effective dose required for an effect in 50% of the population

ED50

23

Median toxic dose required for a toxic effect in 50% of the population

TD50

24

Window between therapeutic effect and toxic effect

Therapeutic index

25

Drug with a high margin of safety

High therapeutic index