Pharm 7

Question 2

Difference between COX 1 and COX 2

Answer 2

*COX 1 is found throughoutthe body and COX 2 is onlyin inflammatory tissue

Question 3

Drug that selectively inhibits COX 2

Answer 3

Celecoxib, valdecoxib, and rofecoxib

Question 4

Major SE of zileuton

Answer 4

Liver toxicity

Question 5

Inhibitor of leukotrienes (LTD4) receptors and used in asthma

Answer 5

Zafirlukast and montelukast

Question 6

Approved for use in severe pulmonary HTN

Answer 6

PGI2 (epoprostenol)

Question 7

Irreversible, nonselective COX inhibitor

Answer 7

Aspirin

Question 8

Class of drugs that reversibly inhibit COX

Answer 8

NSAIDS

Question 9

Primary endogenous substrate for Nitric Oxidase Synthase

Answer 9

Arginine

Question 10

Long acting beta 2 agonist used in asthma

Answer 10

Salmeterol

Question 11

Enzyme which theophylline inhibits

Answer 11

Phosphodiesterase

Question 12

Methylxanthine derivative used as a remedy for intermittent claudication

Answer 12

Pentoxifylline

Question 13

Antidote for severe CV toxicity of theophylline

Answer 13

Beta blockers

Question 14

MOA of corticosteroids

Answer 14

inhibit phospholipase A2

Question 15

MOA of penicillin

Answer 15

Block cell wall synthesis by inhibiting peptidoglycan cross-linkage

Question 16

Type of resistance found with vancomycin

Answer 16

Point mutation

Question 17

Two toxicities of aminoglycosides

Answer 17

nephro and ototoxicity

Question 18

DOC for Legionnaires’ disease

Answer 18

Levofloxacin or azithromycin

Question 19

Penicillins active against penicillinase secreting bacteria

Answer 19

Methicillin, nafcillin, and dicloxacillin

Question 20

Class of antibiotics that have 10% cross sensitivity with penicillins

Answer 20

Cephalosporins

Aztreonam has NO cross sensitivity
- GNR only

Question 21

PCN active against pseudomonas

Answer 21

Carbenicillin, piperacillin and ticarcillin

“TCP”

Question 22

Antibiotic causing red-man syndrome, and prevention

Answer 22

Vancomycin, infusion at a slow rate and antihistamines

Question 23

Drug causes teeth discoloration

Answer 23

Tetracycline

Question 24

MOA of tetracycline

Answer 24

Decreases protein synthesis by inhibiting 30S ribosome

Question 25

Drug that causes gray baby syndrome and aplastic anemia

Answer 25

Chloramphenicol

Question 26

Drug notorious for causing pseudomembranous colitis

Answer 26

Clindamycin

Question 27

Treatment of resistant pseudomembranous colitis

Answer 27

ORAL vancomycin

Question 28

Reason fluoroquinolones are contraindicated in children and pregnancy

Answer 28

Cartilage damage

Question 29

Metronidazole SE if given with alcohol

Answer 29

Disulfiram-like reaction

Question 30

MOA of nystatin

Answer 30

Bind ergosterol in fungal cell membrane

Question 31

Inducers of CYP450

Answer 31

``` Rifampin Griseofulvin Barbiturates Carbamazepine Phenytoin ```