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Flashcards in Pharm 7 Deck (30)
2

Difference between COX 1 and COX 2

*COX 1 is found throughoutthe body and COX 2 is onlyin inflammatory tissue

3

Drug that selectively inhibits COX 2

Celecoxib, valdecoxib, and rofecoxib

4

Major SE of zileuton

Liver toxicity

5

Inhibitor of leukotrienes (LTD4) receptors and used in asthma

Zafirlukast and montelukast

6

Approved for use in severe pulmonary HTN

PGI2 (epoprostenol)

7

Irreversible, nonselective COX inhibitor

Aspirin

8

Class of drugs that reversibly inhibit COX

NSAIDS

9

Primary endogenous substrate for Nitric Oxidase Synthase

Arginine

10

Long acting beta 2 agonist used in asthma

Salmeterol

11

Enzyme which theophylline inhibits

Phosphodiesterase

12

Methylxanthine derivative used as a remedy for intermittent claudication

Pentoxifylline

13

Antidote for severe CV toxicity of theophylline

Beta blockers

14

MOA of corticosteroids

inhibit phospholipase A2

15

MOA of penicillin

Block cell wall synthesis by inhibiting peptidoglycan cross-linkage

16

Type of resistance found with vancomycin

Point mutation

17

Two toxicities of aminoglycosides

nephro and ototoxicity

18

DOC for Legionnaires' disease

Levofloxacin or azithromycin

19

Penicillins active against penicillinase secreting bacteria

Methicillin, nafcillin, and dicloxacillin

20

Class of antibiotics that have 10% cross sensitivity with penicillins

Cephalosporins

Aztreonam has NO cross sensitivity
- GNR only

21

PCN active against pseudomonas

Carbenicillin, piperacillin and ticarcillin

"TCP"

22

Antibiotic causing red-man syndrome, and prevention

Vancomycin, infusion at a slow rate and antihistamines

23

Drug causes teeth discoloration

Tetracycline

24

MOA of tetracycline

Decreases protein synthesis by inhibiting 30S ribosome

25

Drug that causes gray baby syndrome and aplastic anemia

Chloramphenicol

26

Drug notorious for causing pseudomembranous colitis

Clindamycin

27

Treatment of resistant pseudomembranous colitis

ORAL vancomycin

28

Reason fluoroquinolones are contraindicated in children and pregnancy

Cartilage damage

29

Metronidazole SE if given with alcohol

Disulfiram-like reaction

30

MOA of nystatin

Bind ergosterol in fungal cell membrane

31

Inducers of CYP450

Rifampin
Griseofulvin
Barbiturates
Carbamazepine
Phenytoin