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Flashcards in Pharm 2 Deck (25)
2

Drug with a narrow margin of safety

Low therapeutic index

3

Antidote used for lead poisoning

Dimercaprol, EDTA

4

Antidote used for cyanide poisoning

Nitrites

5

Antidote used for anticholinergic poisoning

Physostigmine

6

Antidote used for iron salt toxicity

Deferoxamine

7

Antidote for severe lead poisoning

Dimercaprol + CaEDTA (edetate calcium disodium)

8

Antidote for arsenic, mercury, and gold poisoning

Dimercaprol

9

Antidote used in Wilson's disease (copper poisoning)

Penicillamine

10

Antidote used for methanol and ethylene glycol

Ethanol

11

Antidote used for tricyclic antidepressants (TCA)

Sodium bicarbonate

12

Antidote used for carbon monoxide poisoning

100% O2 and hyperbaric O2

13

Antidote used for digitalis toxicity

Digibind (also need to d/c digoxin, normalize K+, and lidocaine if pt. Is arrhythmic)

14

Antidote used for beta agonist toxicity (eg. Metaproterenol)

Esmolol

15

Antidote for methotrexate toxicity

Leucovorin

16

Antidote for beta-blockers and hypoglycemia

Glucagon

17

Antidote useful for some drug induced Torsade de pointes

Magnesium sulfate

18

Antidote for hyperkalemia

sodium polystyrene sulfonate (Kayexalate)

19

Antidote for salicylate intoxication

Alkalinize urine, dialysis

20

Constant proportion of cell population killed rather than a constant number

Log-kill hypothesis

21

Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously

Pulse therapy

22

Toxic effect of anticancer drug can be lessened by rescue agents

Rescue therapy

23

Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urates

Allopurinol

24

Pyrimidine analog that causes "Thiamine-less death" given with leucovorin rescue

5-flouracil (5-FU)

25

Drug used in cancer therapy causes Cushing-like symptoms

Prednisone

26

Side effect of Mitomycin

SEVERE myelosuppression