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Flashcards in Pharm 8 Deck (33)
2

Neurotoxicity with isoniazid (INH) prevented by

Administration of Vit. B6 (pyridoxine)

3

Toxicity of amphotericin

Nephrotoxicity

4

SE seen only in men with administration of ketoconazole

Gynecomastia

5

Topical DOC in impetigo

Topical mupirocin (Bactroban)

6

DOC for CMV retinitis

Ganciclovir

7

SE for ganciclovir

Myelosuppression

8

Anti-viral agents associated with Steven-Johnson syndrome

Nevirapine, amprenavir

9

Antivirals that are teratogens

Delavirdine, efavirenz, and ribavirin

10

Antivirals associated with neutropenia

Ganciclovir, zidovudine, saquinavir, and interferon

11

HIV med used to reduce transmission during birth

AZT (zidovudine)

12

Drug used for African sleeping sickness

Suramin

13

Drug used in Chagas disease

Nifurtimox

14

Cephalosporins able to cross the BBB

Cefixime (2nd) and 3rd generation

15

Cephalosporin causes kernicterus in neonates

Ceftriaxone or cefuroxime

16

SE of INH

Peripheral neuritis and hepatitis

17

Aminoglycoside that is least ototoxic

Streptomycin

18

Drug used in exoerythrocytic cycle of malaria

Primaquine

19

Oral antibiotic of choice for moderate inflammatory acne

Minocycline

20

Drug of choice for leprosy

Dapsone

21

MOA of erythromycin

Inhibition of protein synthesis at the 50s subunit of ribosome

22

Lactam that can be used in PCN allergic patients

Aztreonam

23

SE of imipenem

Seizures

24

Anti-viral with a dose limiting toxicity of pancreatitis

Didanosine

25

Common side effect of hypnotic agents

Sedation

26

Occurs when sedative hypnotics are used chronically or at high doses

Tolerance

27

The most common type of drug interaction of sedative hypnotics with other depressant medications

Additive CNS depression

28

Neurologic SE of benzodiazepines

Anterograde amnesia

29

Main route of metabolism for benzodiazepines

Hepatic

30

Benzodiazepine that undergo extrahepatic conjugation (which are useful in older or hepatically impaired)

Lorazepam, oxazepam, and temazepam

31

MOA for benzodiazepines

increase the FREQUENCY of GABA-mediated chloride ion channel opening

32

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

Buprenorphine

33

These agents are used as antitussive

Dextromethorphan, Codeine

34

These agents are used as antidiarrheal

Diphenoxylate, Loperamide