Pharm 8

Question 2

Neurotoxicity with isoniazid (INH) prevented by

Answer 2

Administration of Vit. B6 (pyridoxine)

Question 3

Toxicity of amphotericin

Answer 3

Nephrotoxicity

Question 4

SE seen only in men with administration of ketoconazole

Answer 4

Gynecomastia

Question 5

Topical DOC in impetigo

Answer 5

Topical mupirocin (Bactroban)

Question 6

DOC for CMV retinitis

Answer 6

Ganciclovir

Question 7

SE for ganciclovir

Answer 7

Myelosuppression

Question 8

Anti-viral agents associated with Steven-Johnson syndrome

Answer 8

Nevirapine, amprenavir

Question 9

Antivirals that are teratogens

Answer 9

Delavirdine, efavirenz, and ribavirin

Question 10

Antivirals associated with neutropenia

Answer 10

Ganciclovir, zidovudine, saquinavir, and interferon

Question 11

HIV med used to reduce transmission during birth

Answer 11

AZT (zidovudine)

Question 12

Drug used for African sleeping sickness

Answer 12

Suramin

Question 13

Drug used in Chagas disease

Answer 13

Nifurtimox

Question 14

Cephalosporins able to cross the BBB

Answer 14

Cefixime (2nd) and 3rd generation

Question 15

Cephalosporin causes kernicterus in neonates

Answer 15

Ceftriaxone or cefuroxime

Question 16

SE of INH

Answer 16

Peripheral neuritis and hepatitis

Question 17

Aminoglycoside that is least ototoxic

Answer 17

Streptomycin

Question 18

Drug used in exoerythrocytic cycle of malaria

Answer 18

Primaquine

Question 19

Oral antibiotic of choice for moderate inflammatory acne

Answer 19

Minocycline

Question 20

Drug of choice for leprosy

Answer 20

Dapsone

Question 21

MOA of erythromycin

Answer 21

Inhibition of protein synthesis at the 50s subunit of ribosome

Question 22

Lactam that can be used in PCN allergic patients

Answer 22

Aztreonam

Question 23

SE of imipenem

Answer 23

Seizures

Question 24

Anti-viral with a dose limiting toxicity of pancreatitis

Answer 24

Didanosine

Question 25

Common side effect of hypnotic agents

Answer 25

Sedation

Question 26

Occurs when sedative hypnotics are used chronically or at high doses

Answer 26

Tolerance

Question 27

The most common type of drug interaction of sedative hypnotics with other depressant medications

Answer 27

Additive CNS depression

Question 28

Neurologic SE of benzodiazepines

Answer 28

Anterograde amnesia

Question 29

Main route of metabolism for benzodiazepines

Answer 29

Hepatic

Question 30

Benzodiazepine that undergo extrahepatic conjugation (which are useful in older or hepatically impaired)

Answer 30

Lorazepam, oxazepam, and temazepam

Question 31

MOA for benzodiazepines

Answer 31

increase the FREQUENCY of GABA-mediated chloride ion channel opening

Question 32

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

Answer 32

Buprenorphine

Question 33

These agents are used as antitussive

Answer 33

Dextromethorphan, Codeine

Question 34

These agents are used as antidiarrheal

Answer 34

Diphenoxylate, Loperamide