Pharm 17 Flashcards Preview

Step 1 > Pharm 17 > Flashcards

Flashcards in Pharm 17 Deck (32)
2

SE of phenytoin

Gingival hyperplasia

3

Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents

Class IC (flecainide, propafenone, moricizine)

4

Class II antiarrhythmics are

B-blockers

5

Antiarrhythmic that exhibits Class II and III properties

Sotalol

6

Side effect of sotalol

prolongs QT and PR interval

7

Used intravenously for acute arrhythmias during surgery

Esmolol

8

Anti-arrhythmics that decrease mortality

B-blockers

9

MOA of class III antiarrhythmics

Potassium channel blockers

10

Class III antiarrhythmic that exhibits properties of all 4 classes

Amiodarone

11

Specific pharmacokinetic characteristic of amiodarone

Prolonged half-life, up to six weeks

12

Antiarrhythmic effective in most types of arrhythmia

Amiodarone

13

SE of Amiodarone

Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis

14

MOA of class IV antiarrhythmics

Calcium channel blockers

15

Agent to treat torsades de pointes

Magnesium sulfate

16

Drug used supraventricular arrhythmias

Digoxin

17

DOC for paroxysmal supraventricular tachycardia (PSVT)

Adenosine

18

Adenosine's MOA

Activates acetylcholine sensitive K+ channels in SA and AV node

19

Anti-arrhythmic with <10 second duration of action

Adenosine

20

Drugs used in the management of angina

Aspirin, Nitrates, CCB, and Beta blockers

21

Aspirin reduces mortality in unstable angina by

Platelet aggregation inhibition

22

Nitrate used for acute anginal attacks

Nitroglycerin sublingual tablets

23

Nitrate used to prevent further attacks

Oral and transdermal forms of nitroglycerin

24

Nitrate free intervals are needed due to

Tolerance

25

SE of nitrates

Postural hypotension, reflex tachycardia, hot flashes, and throbbing headache due to meningeal artery dilation

26

CCB are DOC for

Prinzmetal's angina

27

Beta blockers are used for which type of anginal attack

Classic

28

MOA of Cardiac glycosides (eg. digoxin)

Indirectly increase intracellular calcium and cardiac contractility by inhibit Na+/K+ ATPase

29

Digoxin is used in

Atrial fibrillation and CHF

30

Digoxin toxicity can be precipitated by

Hypokalemia

31

Antidote for digoxin toxicity

Digibind

32

Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects

Amrinone and milrinone

33

SE of amrinone

Thrombocytopenia