Pharm 17

Question 2

SE of phenytoin

Answer 2

Gingival hyperplasia

Question 3

Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents

Answer 3

Class IC (flecainide, propafenone, moricizine)

Question 4

Class II antiarrhythmics are

Answer 4

B-blockers

Question 5

Antiarrhythmic that exhibits Class II and III properties

Answer 5

Sotalol

Question 6

Side effect of sotalol

Answer 6

prolongs QT and PR interval

Question 7

Used intravenously for acute arrhythmias during surgery

Answer 7

Esmolol

Question 8

Anti-arrhythmics that decrease mortality

Answer 8

B-blockers

Question 9

MOA of class III antiarrhythmics

Answer 9

Potassium channel blockers

Question 10

Class III antiarrhythmic that exhibits properties of all 4 classes

Answer 10

Amiodarone

Question 11

Specific pharmacokinetic characteristic of amiodarone

Answer 11

Prolonged half-life, up to six weeks

Question 12

Antiarrhythmic effective in most types of arrhythmia

Answer 12

Amiodarone

Question 13

SE of Amiodarone

Answer 13

Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis

Question 14

MOA of class IV antiarrhythmics

Answer 14

Calcium channel blockers

Question 15

Agent to treat torsades de pointes

Answer 15

Magnesium sulfate

Question 16

Drug used supraventricular arrhythmias

Answer 16

Digoxin

Question 17

DOC for paroxysmal supraventricular tachycardia (PSVT)

Answer 17

Adenosine

Question 18

Adenosine’s MOA

Answer 18

Activates acetylcholine sensitive K+ channels in SA and AV node

Question 19

Anti-arrhythmic with <10 second duration of action

Answer 19

Adenosine

Question 20

Drugs used in the management of angina

Answer 20

Aspirin, Nitrates, CCB, and Beta blockers

Question 21

Aspirin reduces mortality in unstable angina by

Answer 21

Platelet aggregation inhibition

Question 22

Nitrate used for acute anginal attacks

Answer 22

Nitroglycerin sublingual tablets

Question 23

Nitrate used to prevent further attacks

Answer 23

Oral and transdermal forms of nitroglycerin

Question 24

Nitrate free intervals are needed due to

Answer 24

Tolerance

Question 25

SE of nitrates

Answer 25

Postural hypotension, reflex tachycardia, hot flashes, and throbbing headache due to meningeal artery dilation

Question 26

CCB are DOC for

Answer 26

Prinzmetal's angina

Question 27

Beta blockers are used for which type of anginal attack

Answer 27

Classic

Question 28

MOA of Cardiac glycosides (eg. digoxin)

Answer 28

Indirectly increase intracellular calcium and cardiac contractility by inhibit Na+/K+ ATPase

Question 29

Digoxin is used in

Answer 29

Atrial fibrillation and CHF

Question 30

Digoxin toxicity can be precipitated by

Answer 30

Hypokalemia

Question 31

Antidote for digoxin toxicity

Answer 31

Digibind

Question 32

Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects

Answer 32

Amrinone and milrinone

Question 33

SE of amrinone

Answer 33

Thrombocytopenia