Chemical Pathology 19 - Lipid Update Flashcards Preview

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Flashcards in Chemical Pathology 19 - Lipid Update Deck (11)
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1

What is the statistical mortality benefit of adding a thiazide diuretic to outstanding BP medications, following an MI?

Worth it, as 2 in 100 will be prevented from a further MI in the next 5 years

2

What is the statistical mortality benefit of adding a PCSK9 inhibitor to outstanding BP medications, following an MI?

Decreases incidence of non-fatal MI, but does not reduce death

3

Give an example of a PCSK9 inhibitor medication, and how it works

Evolocumab
Regulates LDL-receptor recycling to reduce cholesterol

4

What did the UKPDS study show?

That it takes 15 years for good glucose control to show a benefit

5

What did the Advance study show?

Slightly less intense intervention into glucose control actually reduce death compared to super-intense intervention

6

What did the Accord study show?

If you take someone who already has knackered coronary arteries and suddenly tighten glucose control, motality actually increases

7

What did the DCCT show?

Good control in type 1 diabetes improves outcome

8

What makes SGLT2 inhibitors such a fabulous drug class according to Meeran?

Reduce HbA1c, BP, weight, type 2 diabetes incidence and cardiovascular disease, with immediate effect!

9

What is the broad mechanism of action of SGLT2 inhibitors?

They cause glycosuria

10

Give an example of a GLP-1 analogue drug

Semaglutide

11

What is the mechanism of action of the 'gliptin' drugs?

DPP4 inhibitors

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